Citation: Xin DENG, Fu-Xing ZHANG, Jing-Jing QING, Ge YANG, Fan HE, Li-Fang HE, Zhi-Hui LIU, Shuai-Peng HOU. Synthesis, structure, and anticancer activity of two benzohydroxamic acid organotin complexes[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(11): 2083-2090. doi: 10.11862/CJIC.2023.182 shu

Synthesis, structure, and anticancer activity of two benzohydroxamic acid organotin complexes

  • Corresponding author: Fu-Xing ZHANG, zfx8056@163.com
  • Received Date: 23 May 2023
    Revised Date: 27 September 2023

Figures(5)

  • Two benzohydroxamic acid organotin complexes[(o-Cl-C6H4CH2)2Sn(C6H5CONO)2] (1) and[(o-CH3-C6H4CH2)2Sn(C6H5CONO) (C6H5COO)] (2) were synthesized by solvothermal method using methanol as a solvent. Complexes 1 and 2 were characterized by elemental analysis, IR, 1H NMR, thermogravimetric analysis, single-crystal X-ray diffraction, etc. The study on the complexes has been performed with quantum chemistry calculation and in vitro anticancer activity. The results show that the two complexes are monotin nuclear structures; complexes 1 and 2 are the six-coordinated distorted octahedron configuration and seven-coordinated distorted triangular bipyramid configuration, respectively. Complex 1 showed stronger inhibitory activity on human cervical cancer cells (HeLa), hepatoma cells (HuH-7), and lung adenocarcinoma cells (H1975) than cisplatin, while complex 2 showed much weaker inhibitory activity.
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