Citation: Xiao-Shuang ZHU, Xue-Zhi GAO, Rui WANG, Yan-Hong YANG, Jia-Wei LIANG, Bing LI. Bovine serum albumin binding property of Dy(Ⅲ) and Tm(Ⅲ) complexes based on pyridine-2-carboxylic acid[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(7): 1360-1368. doi: 10.11862/CJIC.2023.111 shu

Bovine serum albumin binding property of Dy(Ⅲ) and Tm(Ⅲ) complexes based on pyridine-2-carboxylic acid

State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, Department of Chemistry & Chemical Engineering, Ningxia University, Yinchuan 750021, China

Corresponding author: Bing LI, nxdaxue@126.com
Received Date: 28 November 2022
Revised Date: 27 April 2023

Figures(4)

Two isomorphous mononuclear complexes [M(tpc)₃(H₂O)₃]·H₂O, where M=Dy (1), Tm (2), were synthesized through the reaction of 5-(trifluoromethyl) pyridine-2-carboxylic acid (Htpc), DyCl₃·6H₂O, and TmCl₃·3H₂O. The crystallographic details of complexes 1 and 2 reveal a monoclinic crystal system with the P2₁/c space group. Metal ions in the two complexes are eight-coordinated and located in the slightly deformed dodecahedron geometry. The fluorescence data reveal that complexes 1 and 2 could interact with bovine serum albumin (BSA) through the static quenching mechanism with the quenching constant K_sv ranging from 10⁵ to 10⁶ L·mol^-1. Hydrophobic interaction plays an important role in the interaction of complexes and BSA since both ΔH and ΔS values are positive. The binding constant between the two complexes and BSA was about 10⁴ L·mol^-1 at 25 ℃, which indicates the complexes and BSA have moderate interactions.
- lanthanide complexes,
- 5-(trifluoromethyl) pyridine-2-carboxylic acid,
- bovine serum albumin,
- static quenching
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