Citation: Jian-Chao SHI, Yu-Man TIAN, Wei-Na WU, Yuan WANG, Xiao-Xia LI. A quinoxaline-containing Schiff base probe for the selective and sensitive detection of Zn²⁺ and imaging application in living cells[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(7): 1295-1302. doi: 10.11862/CJIC.2023.110 shu

A quinoxaline-containing Schiff base probe for the selective and sensitive detection of Zn²⁺ and imaging application in living cells

1.
School of Medicine, Henan Polytechnic University, Jiaozuo, Henan 454000, China
2.
Henan Key Laboratory of Coal Green Conversion, College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, China
3.
Institute of Functional Materials, Jiangxi University of Finance and Economics, Nanchang 330013, China

Corresponding author: Wei-Na WU, wuwn08@hpu.edu.cn Xiao-Xia LI, lixiaoxia04@sina.com
Received Date: 21 November 2022
Revised Date: 19 April 2023

Figures(10)

A Schiff base probe, namely N′ -(quinoxaline-2-ylmethylene) pyridinyl hydrazide (1) was produced by a simple condensation reaction and was fully characterized through 1H NMR, 13C NMR, and ESI-MS. Probe 1 was nonemissive while displaying a strong emission at 500 nm in the presence of Zn²⁺. This fluorescence enhancement was highly selective and sensitive toward Zn²⁺ over other common cations, with a detection limit of 0.16 μmol·L^-1. The coordination mode of 1 with Zn²⁺ was proposed by means of ESI-MS, ¹H NMR, and UV-Vis. The crystal structure of the 1-Zn²⁺ complex was characterized by X- ray single- crystal diffraction, further confirming the coordination behavior of the probe. The results showed that the probe can coordinate two independent Zn²⁺ ions via ONN and NN donor sets, which are connected by bridged CH₃O^- and Cl^- to form a 1D chain. Finally, the probe was used to trace Zn²⁺ in HeLa cells.
- fluorescent probe,
- quinoxaline,
- Schiff base,
- Zn²⁺,
- cell imaging
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

A quinoxaline-containing Schiff base probe for the selective and sensitive detection of Zn2+ and imaging application in living cells

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通讯作者: 陈斌, bchen63@163.com

A quinoxaline-containing Schiff base probe for the selective and sensitive detection of Zn²⁺ and imaging application in living cells