Citation: Fu-Xing ZHANG, Xin DENG, Zhe-Hao YANG, Xin ZHANG, Kang-Xia FU, Liang-Bing SHENG, Xiao-Ming ZHU, Wu-Jiu JIANG, Jiang-Xi YU. Synthesis, structure, and anticancer activity of organotin 9-fluorenone-4-carboxylates[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(7): 1287-1294. doi: 10.11862/CJIC.2023.092 shu

Synthesis, structure, and anticancer activity of organotin 9-fluorenone-4-carboxylates

Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Fu-Xing ZHANG, zfx8056@163.com
Received Date: 22 November 2022
Revised Date: 31 March 2023

Figures(8)

Three organotin 9-fluorenone-4-carboxylate compounds, triphenyltin 9‑fluorenone‑4‑carboxylate [(C₆H₅)₃Sn(C₁₄H₇O₃)] (1), tricyclohexyltin 9-fluorenone-4-carboxylate [(C₆H₁₁)₃Sn(C₁₄H₇O₃)] (2), and tri(2-methyl-2-phenylpropyl) tin 9-fluorenone-4-carboxylate [(C₆H₅C(CH₃)₂CH₂)₃Sn(C₁₄H₇O₃)] (3), were synthesized by the solvothermal method using methanol as a solvent. The compounds were characterized by elemental analysis, IR spectroscopy, NMR (¹H, ¹³C, and ¹¹⁹Sn), and thermogravimetric analysis. The crystal structures of the compounds were determined by single-crystal X-ray diffraction. The compounds were studied by quantum chemical calculation and in vitro anticancer activity. The results show that compound 1 has a 1D chain structure and the central tin atom is a five-coordinated distorted trigonal bipyramid configuration; compounds 2 and 3 are single tin nuclear molecules and the tin atoms are four-coordinated distorted tetrahedron configurations. The compounds have good inhibitory activity on the human cervical carcinoma cell line (HeLa), human liver cancer cell line (HUH-7), human non-small cell lung cancer cell line (A549), human lung adenocarcinoma cell line (H1975) and breast cancer cell line (MCF-7).
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