Citation: Yu-Yun ZHENG, Jing-Hong LIU, Jia-Yun CHEN, Jian-Ming OUYANG. Effects of supersaturation, Ca²⁺/C₂O₄^2- stoichiometric ratio on calcium oxalate crystallization and the regulation of degraded Poria cocos polysaccharide[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(5): 794-804. doi: 10.11862/CJIC.2023.058 shu

Effects of supersaturation, Ca²⁺/C₂O₄^2- stoichiometric ratio on calcium oxalate crystallization and the regulation of degraded Poria cocos polysaccharide

College of Chemistry and Materials Science, Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China

Corresponding author: Jian-Ming OUYANG, toyjm@jnu.edu.cn
Received Date: 19 July 2022
Revised Date: 15 March 2023

Figures(7)

To study the nucleation, growth, and aggregation of calcium oxalate (CaC₂O₄) crystals, and to explore the inhibitory effect of degraded Poria cocos polysaccharide (PCP), CaC₂O₄ crystals formed under different conditions were characterized by X-ray diffraction, FT-IR, scanning electron microscope, Raman spectroscopy, ζ potentiometer, and UV spectrophotometer. The results showed that calcium oxalate monohydrate (COM) crystals were mainly formed at low supersaturation (RS ≤ 26.6). At RS being 37.6 and 46.0, 11.6% and 38.3% calcium oxalate dihydrate (COD) crystals were formed respectively, and the aggregation degree of the crystals increased at high RS. At the same RS, the proportion of COD in the crystal increased with the increase of the Ca²⁺/Ox^2- stoichiometric ratio (n_Ca²⁺/n_Ca^2-, Ox^2-=C₂O₄^2-). The addition of degraded PCP could increase the concentration of soluble Ca²⁺ ions in the system, reduce the quality of generated CaC₂O₄ crystals, and increase the absolute value of ζ potential on the crystal surface, all of which are beneficial to inhibit the formation of CaC₂O₄ stones. Thus, the risk of high Ox^2- concentration on the formation of kidney stones is much greater than that of high Ca²⁺ concentration, suggesting that the risk of oxalic acid intake on CaC₂O₄ stones is much greater than that of calcium intake. PCP can simultaneously inhibit the nucleation, growth, and aggregation of CaC₂O₄ crystals.
- calcium oxalate,
- Poria cocos polysaccharide,
- Ca²⁺/Ox^2- stoichiometric ratio,
- supersaturation,
- crystal regulation
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Effects of supersaturation, Ca2+/C2O42- stoichiometric ratio on calcium oxalate crystallization and the regulation of degraded Poria cocos polysaccharide

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通讯作者: 陈斌, bchen63@163.com

Effects of supersaturation, Ca²⁺/C₂O₄^2- stoichiometric ratio on calcium oxalate crystallization and the regulation of degraded Poria cocos polysaccharide