Citation: Si-Jia YI, Xia HE, Shu-Qi GU, Zhe-Yu DENG, Jia-Hong LI, Jiang-Xi YU, Fu-Xing ZHANG, Xiao-Ming ZHU. Microwave solvothermal syntheses, crystal structures, and in vitro antitumor activity of three organotin 2, 2′-biphenyl dicarboxylate[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(5): 874-882. doi: 10.11862/CJIC.2023.050 shu

Microwave solvothermal syntheses, crystal structures, and in vitro antitumor activity of three organotin 2, 2′-biphenyl dicarboxylate

Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Xiao-Ming ZHU, zxmhunhy@163.com
Received Date: 24 November 2022
Revised Date: 24 March 2023

Figures(5)

Three organotin 2, 2′-biphenyl dicarboxylates, namely [((PhC(Me)₂CH₂)₃Sn)₂(DPA)] (1), [(Cy)₃Sn(DPA)]_n (2), and [(n-Bu)₂Sn(DPA)]_n (3), have been prepared by the microwave-assisted solvothermal reaction of 2, 2′-biphenyl dicarboxylic acid (H₂DPA) with bis(tri(2-methyl-2-phenyl)propyl)tin oxide, tricyclohexyltin hydroxide, and dibutyltin oxide, respectively. Complexes 1-3 have been characterized by IR, NMR, elemental analysis, and thermogravimetry, and the crystal structures have been determined by X-ray diffraction. The crystals of 1-3 belong to the monoclinic system. Due to the influence of alkyl group steric, the steric resistance of the group for PhC(Me)₂CH₂ (1) > Cy (2) > n-Bu (3), the coordination number of tin atoms of complexes 1-3 increases successively, and the coordination number of tin atoms are 4, 5, and 6, respectively. Complex 1 has a binuclear structure, and complexes 2 and 3 are 1D chain structures. The antitumor activity shows that complexes 1-3 have higher activities than cisplatin in Human lung cancer cells (NCI-H460), human breast adenocarcinoma cells (MCF-7), and human liver cancer cells (HepG2) line in vitro.
- organotin 2, 2′-biphenyldicarboxylate,
- microwave solvothermal synthesis,
- crystal structure,
- in vitro antitumor activity
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