Citation: Ting-Ying YANG, Dan GUO, Yu-Qiong HU, Si-Jia YI, Shu-Qi GU, Xia HE, Xiao-Ming ZHU, Fu-Xing ZHANG. Synthesis, structure, and properties of multinuclear Ca(Ⅱ) and binuclear Mn(Ⅱ) complexes assembled by 1, 10-phenanthroline and 1-naphthalic acid ligands[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(1): 117-126. doi: 10.11862/CJIC.2022.282 shu

Synthesis, structure, and properties of multinuclear Ca(Ⅱ) and binuclear Mn(Ⅱ) complexes assembled by 1, 10-phenanthroline and 1-naphthalic acid ligands

Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Xiao-Ming ZHU, zxmhunhy@163.com Fu-Xing ZHANG, zfx8056@163.com
Received Date: 18 July 2022
Revised Date: 10 November 2022

Figures(7)

Two complexes [Ca(Phen)(Nap)₂]_n (1) and [Mn₂(Phen)₂(Nap)4(H₂O)] (2) were synthesized by calcium acetate monohydrate or manganous acetate reacting with 1, 10-phenanthroline (Phen) and 1-naphthoic acid (HNap). Complexes 1 and 2 have been characterized by IR, elemental analysis, and thermogravimetry and the crystal structures have been determined by X-ray diffraction. Both the central calcium ion and the central manganese ion form a six-coordinated twisted octahedral structure. The excitation spectrum and emission spectrum of the two complexes were determined, and the results showed that the excitation and emission spectra of the complexes had a good mirror relationship, and the Stokes shift of complex 2 was greater than that of complex 1. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines, namely human lung cancer cells (NCI-H460), human breast cancer cells (MCF-7), human liver cancer cells (HepG2), and human normal cells (HL7702). It was found that complexes 1 and 2 showed a good inhibitory effect on the three cancer cells, compared to the normal cell. The interactions of the complexes with calf thymus DNA have been studied by UV and fluorescence spectroscopy, and the results show that the binding mode of complexes 1 and 2 with DNA may most likely bind in the groove of the DNA backbone by electrostatic action, and their intrinsic binding constants were 5.83×10³ and 6.43×10³ L·mol^-1, respectively. Complex 1 showed no redshift, while complex 2 showed an obvious redshift of 2.0 nm. The subtractive effect, intrinsic binding constants, and the redshift data indicate that the interaction between complex 2 and DNA is greater than that between complex 1 and DNA.
- multinuclear Ca(Ⅱ) complex,
- binuclear Mn(Ⅱ) complex,
- crystal structure,
- DNA-binding,
- in vitro antitumor activity
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