Citation: Xun-Yi LI, Yu-Jing WANG, Zi-Mo ZHOU, Xiao FANG, Qing-Qing WANG, Mei-Chun HU, Xiao-Song YANG, Xiao-Bo WANG. Synthesis, crystal structure, and anticancer activity of a polypyridyl binuclear monofunctional platinum(Ⅱ) complex[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(1): 141-149. doi: 10.11862/CJIC.2022.272 shu

Synthesis, crystal structure, and anticancer activity of a polypyridyl binuclear monofunctional platinum(Ⅱ) complex

Xun-Yi LI ^{1, 2} ,
Yu-Jing WANG ¹ ,
Zi-Mo ZHOU ^{1, 3} ,
Xiao FANG ¹ ,
Qing-Qing WANG ¹ ,
Mei-Chun HU ² ,
Xiao-Song YANG ^3,, ,
Xiao-Bo WANG ^1,,

1.
School of Pharmacy, Medical Department, Hubei University of Science and Technology, Xianning, Hubei 437100, China
2.
Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, Hubei 437100, China
3.
School of Basic Medical Sciences, Medical Department, Hubei University of Science and Technology, Xianning, Hubei 437100, China

Corresponding author: Xiao-Song YANG, xiaosong_yang@hbust.edu.cn Xiao-Bo WANG, eas7on@163.com
Received Date: 28 June 2022
Revised Date: 16 November 2022

Figures(6)

A binuclear monofunctional platinum(Ⅱ) complex, [Pt₂(BPA-TPA)Cl₂]Cl₂ (Pt₂-BPA-TPA), containing polypyridyl ligand 2, 6-bis((bis(pyridin-2-ylmethyl)amino)methyl)pyridine was synthesized and characterized by nuclear magnetic resonance and high-resolution mass spectroscopy. In addition, the structure of Pt₂-BPA-TPA was determined by X-ray single-crystal diffraction. Agarose gel electrophoresis experiments were used to demonstrate the efficient pBR322 DNA-cleaving activity of Pt₂-BPA-TPA at a low concentration of 10 μmol·L^-1. In CCK-8 (cell counting kit-8) cytotoxicity studies using the A549 human lung cancer cell line, Pt₂-BPA-TPA demonstrated enhanced anticancer activity compared with cisplatin. Mechanistic studies provided evidence that Pt₂-BPA-TPA induces apoptosis via triggering DNA damage and upregulating downstream cellular signaling cascades of p21 and cleaved-caspase-3.
- monofunctional platinum(Ⅱ),
- anticancer activity,
- DNA cleavage,
- binuclear complex,
- crystal structure
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