Citation: Hui GUO, Tao WANG, Wen-Qing SU, Dan LI, Xing-Xing CHEN, Jie-Ying WU, Qiong ZHANG, Yu-Peng TIAN. Synthesis, Structure, and Interaction with DNA of Alkoxy Tribipyridine Ruthenium Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(10): 2019-2027. doi: 10.11862/CJIC.2022.202 shu

Synthesis, Structure, and Interaction with DNA of Alkoxy Tribipyridine Ruthenium Complexes

Hui GUO ¹ ,
Tao WANG ² ,
Wen-Qing SU ¹ ,
Dan LI ¹ ,
Xing-Xing CHEN ¹ ,
Jie-Ying WU ¹ ,
Qiong ZHANG ^{1, 3,,} ,
Yu-Peng TIAN ^{1, 3,,}

1.
Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230601, China
2.
School of Life Science, Anhui University, Hefei 230601, China
3.
State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210023, China

Corresponding author: Qiong ZHANG, zhangqiong.314@163.com Yu-Peng TIAN, yptian@ahu.edu.com
Received Date: 9 April 2022
Revised Date: 16 August 2022

Figures(10)

Two ruthenium complexes (Ru-Cl, Ru-NCMe) containing long alkoxy tribipyridine and 2, 2′-bipyridine were synthesized and characterized by mass spectrometry, NMR, single crystal X-ray diffraction analysis, etc. Based on their crystal structural information, it can be found that the sixth coordination position in complex Ru-Cl is Cl^- ion, and the sixth coordination position in complex Ru-NCME is N atom in acetonitrile molecule. The interaction of the two complexes with various amino acids and DNA was studied by UV-Vis absorption and fluorescence spectros-copy. It was found that the complexes with long alkyl chains and rigid coordination planes had an obvious specific recognition effect on DNA. Further study found that they could bind DNA in the way of insertion and electrostatic. Both results of the experiments and the theoretical calculation were consistent.
- Ru(Ⅱ) complexes,
- tribipyridine,
- crystal structures,
- DNA response
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