Citation: Shi-Fang JIA, Xiu-Li HAO, Yan-Zhen WEN, Yan ZHANG. Synthesis, Characterization, and Antitumor Activity of Ruthenium(Ⅱ) Complexes Based on Schiff Base Ligand[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(10): 1919-1926. doi: 10.11862/CJIC.2022.191 shu

Synthesis, Characterization, and Antitumor Activity of Ruthenium(Ⅱ) Complexes Based on Schiff Base Ligand

School of Chemical and Biological Engineering, Taiyuan Science and Technology University, Taiyuan 030021, China

Corresponding author: Yan ZHANG, yanzhang872010@163.com
Received Date: 25 November 2021
Revised Date: 6 June 2022

Figures(7)

A series of new Schiff base ligands (BLⁿ, n=1 - 3) and complexes have been synthesized. Binuclear ruthenium complexes [Ru(BLⁿ)(bpy)₂]₂(ClO₄)₄, where bpy=2, 2'-bipyridine, BLⁿ=((PyCHN)-Ph-O-C₆H₄) ₂R (PyCHN=N-2-pyridylmethylene, R=none for Ru1, —C(CH₃)₂ for Ru2 and —SO₂ for Ru3), have been prepared and characterized by element analysis, ¹H NMR, IR, and mass spectrometry methods. The cytotoxicity to cervical cancer cells (Hela), gastric cancer cells (BGC823), gastric cancer cells (SGC-7901), and human normal embryonic lung fibroblasts cells (MRC-5) of the three complexes in vitro was evaluated using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. It is worth noting that Ru1-Ru3 showed excellent antitumor effects in a cellular study for BGC823 in vitro. However, Ru3 exhibited the highest cytotoxicity to any cancer cells than Ru1 and Ru2.
- Schiff base ligand,
- binuclear ruthenium complexes,
- cytotoxicity
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