Citation: Yu-Lin ZHOU, Fu-Xing ZHANG, Xiao-Ming ZHU, Jie TIAN, Sai-Nan XU, Bin-Jie ZHAO, Jing-Jiao CHEN, Fang-Fang LI, Xin DENG. Synthesis, Structure, and Anticancer Activity of Two Organotin Heterocyclic Carboxylates Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(8): 1533-1540. doi: 10.11862/CJIC.2022.161 shu

Synthesis, Structure, and Anticancer Activity of Two Organotin Heterocyclic Carboxylates Complexes

Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials of University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Fu-Xing ZHANG, zfx8056@163.com
Received Date: 12 February 2022
Revised Date: 26 April 2022

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Two organotin heterocyclic carboxylate complexes di(o - bromobenzyl)tin bis(2-pyridinecarboxylate) (1) and tri(2-methyl-2-phenyl propyl)tin 3-indole butyrate (2) have been synthesized by a solvothermal method using methanol as solvent. The complexes were characterized by elemental analysis, IR spectroscopy, NMR (¹H, ¹³C, and ¹¹⁹Sn), X-ray diffraction, and thermogravimetric analysis. The crystal structures of the complexes were determined by X-ray single-crystal diffraction. The results show that the complexes have a single tin core structure, and the tin atoms are six-coordinate distorted octahedron configuration and four-coordinate distorted tetrahedron configuration respectively. The stabilities, orbital energies, and composition characteristics of some frontier molecular orbitals of 1 and 2 have been carefully investigated with quantum chemistry calculation. In addition, the in vitro antitumor activities suggest that 1 and 2 had higher activities than cisplatinum against human hepatoma cells (HUH7), human lung cancer cells (A549), human epidermal cancer cells (A431), human colon cancer cells (HCT-116), and breast cancer cells (MDA-MB-231).
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