Citation: Yu-Lin ZHOU, Fu-Xing ZHANG, Xiao-Ming ZHU, Jie TIAN, Sai-Nan XU, Bin-Jie ZHAO, Jing-Jiao CHEN, Fang-Fang LI, Xin DENG. Synthesis, Structure, and Anticancer Activity of Two Organotin Heterocyclic Carboxylates Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(8): 1533-1540. doi: 10.11862/CJIC.2022.161 shu

Synthesis, Structure, and Anticancer Activity of Two Organotin Heterocyclic Carboxylates Complexes

  • Corresponding author: Fu-Xing ZHANG, zfx8056@163.com
  • Received Date: 12 February 2022
    Revised Date: 26 April 2022

Figures(6)

  • Two organotin heterocyclic carboxylate complexes di(o - bromobenzyl)tin bis(2-pyridinecarboxylate) (1) and tri(2-methyl-2-phenyl propyl)tin 3-indole butyrate (2) have been synthesized by a solvothermal method using methanol as solvent. The complexes were characterized by elemental analysis, IR spectroscopy, NMR (1H, 13C, and 119Sn), X-ray diffraction, and thermogravimetric analysis. The crystal structures of the complexes were determined by X-ray single-crystal diffraction. The results show that the complexes have a single tin core structure, and the tin atoms are six-coordinate distorted octahedron configuration and four-coordinate distorted tetrahedron configuration respectively. The stabilities, orbital energies, and composition characteristics of some frontier molecular orbitals of 1 and 2 have been carefully investigated with quantum chemistry calculation. In addition, the in vitro antitumor activities suggest that 1 and 2 had higher activities than cisplatinum against human hepatoma cells (HUH7), human lung cancer cells (A549), human epidermal cancer cells (A431), human colon cancer cells (HCT-116), and breast cancer cells (MDA-MB-231).
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