Citation: Xiao-Lin GUAN, Yuan-Yuan DING, Shou-Jun LAI, Xue-Qin YANG, Jing-Yu WEI, Jia-Ming ZHANG, Li-Yuan ZHANG, Jin-Hui TONG, Zi-Qiang LEI. Ultra-small Size Rare Earth Complex Fluorescent Nanoprobe for Dual Color Imaging of Tumor Cells Constructed with PCL-b-PNIPAM Coordinated Eu(Ⅲ)[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(6): 1023-1036. doi: 10.11862/CJIC.2022.097 shu

Ultra-small Size Rare Earth Complex Fluorescent Nanoprobe for Dual Color Imaging of Tumor Cells Constructed with PCL-b-PNIPAM Coordinated Eu(Ⅲ)

1.
Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
2.
School of Chemical Engineering, Lanzhou University of Arts and Science, Lanzhou 730000, China

Corresponding author: Xiao-Lin GUAN, guanxiaolin@nwnu.edu.cn
Received Date: 30 August 2021
Revised Date: 24 February 2022

Figures(6)

Three amphiphilic block copolymers 1s-TPE-PCL-b-PNIPAM, 2s-TPE-PCL-b-PNIPAM, and 4s-TPE-PCL -b-PNIPAM (PCL=polycaprolactone, PNIPAM=poly(N - isopropylacrylamide)) were synthesized by in situ polymerization with tetraphenylethylene (TPE) fluorescent small molecules as the center. Then, the rare earth element Eu(Ⅲ) was coordinated with the hydrophilic fragment PNIPAM to synthesize block copolymer-Eu(Ⅲ) complexes (1s-TPE-PCL-b-PNIPAM-Eu(Ⅲ) for one-arm, 2s-TPE-PCL-b -PNIPAM-Eu(Ⅲ) for two-arm, and 4s-TPE-PCL-b-PNIPAM-Eu(Ⅲ) for four-arm). Finally, non-semiconductor polymer dots (Pdots) were prepared by self-assembly of the complexes in water. The three kinds of Pdots had excellent water solubility and ultra-small particle size below 5 nm (average particle sizes were 4.8, 4.3, and 2.7 nm, respectively). The optical test results showed that the single, double, and fourarm Pdots mainly emitted blue light at 430 nm under the excitation of 360 nm, and exhibited excellent aggregation-induced emission characteristics. At 395 nm, the red emission was mainly at 615 nm, and there had little mutual interference because of blue-red emission wavelength spacing was as high as 195 nm, showing excellent double fluorescence properties. The four-arm Pdots aqueous solution had a wider range of color changes and a better double fluorescence effect. In addition, the lower critical solution temperatures (LCSTs) of the three Pdots were 32, 36, and 37 ℃, respectively. While the LCSTs of the four -arm Pdots were closer to the normal body temperature. At the same time, the conformation of the PNIPAM chain in Pdots changed from expansion state to contraction state along with the increase of temperature. As a result, the aggregation degree of TPE on the chain was enhanced, which caused the temperature response of Pdots aqueous solution fluorescence. Ultimately, cytotoxicity and cell imaging studies showed that the three Pdots had low cytotoxicity and could enter HeLa, A549, and HepG2 tumor cells by endocytosis. Under different excitation wavelengths, strong blue or red fluorescence signals could be received in the cells, exhibiting blue/red dual-color fluorescence imaging ability and reversible dual-color fluorescence switching function. In addition, the comparison of the three Pdots found that the four-arm Pdots had the smallest particle size, the best dual fluorescence performance, and the best cell imaging effect.
- polymer dots,
- amphiphilic block copolymer,
- Eu(Ⅲ) complex,
- small size,
- dual fluorescence,
- cell imaging
1. [1]
  Li H Y, Wang C F, Hou T, Li F. Amphiphile - Mediated Ultrasmall Aggregation Induced Emission Dots for Ultrasensitive Fluorescence Biosensing[J]. Anal. Chem., 2017,89(17):9100-9107. doi: 10.1021/acs.analchem.7b01797
2. [2]
  Wang X, Li P, Ding Q, Wu C C, Zhang W, Tang B. Observation of Acetylcholinesterase in Stress - Induced Depression Phenotypes by Two-Photon Fluorescence Imaging in the Mouse Brain[J]. J. Am. Chem. Soc., 2019,141(5):2061-2068. doi: 10.1021/jacs.8b11414
3. [3]
  Meng F F, Wang J P, Ping Q N, Yeo Y. Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited[J]. ACS Nano, 2018,12(7):6458-6468. doi: 10.1021/acsnano.8b02881
4. [4]
  ZHOU M X, REN N, ZHANG J J. Four Rare Earth Complexes with Chlorinated Carboxylic Acids and Bipyridine Ligands: Crystal Structures, Thermal Analysis and Luminescence Properties[J]. Chinese J. Inorg. Chem., 2020,36(12):2349-2358. doi: 10.11862/CJIC.2020.258
5. [5]
  Qiao G X, Lai Z J, Gao J W, Liu W Q, Zheng Y H. Lanthanide Molecular Model Triggers Sequential Sensing Performance[J]. J. Mol. Liq., 2020,311113344. doi: 10.1016/j.molliq.2020.113344
6. [6]
  Cota L, Marturano V, Tylkowski B. Ln Complexes as Double Faced Agents: Study of Antibacterial and Antifungal Activity[J]. Coord. Chem. Rev., 2019,396:49-71. doi: 10.1016/j.ccr.2019.05.019
7. [7]
  ZHANG Q R, DENG R P, LIU Y B, ZHOU L, ZHANG H J. Near Infrared Luminescence Properties of the Complexes of Er_xYb_1-x(TPB)₃Bath (x= 0, 0.218, 0.799, 0.896, 0.987, 1)[J]. Chinese J. Inorg. Chem., 2017,33(11):2011-2016. doi: 10.11862/CJIC.2017.254
8. [8]
  Li G D, Wu C, Ma D L, Leunga C. Drug Screening Strategies Using Metal - Based Luminescent Probes[J]. Trac - Trends Anal. Chem., 2021,139:116270-116287. doi: 10.1016/j.trac.2021.116270
9. [9]
  Zhou R H, Li Y J, Xiao D X, Li T, Zhang T, Fu W, Lin Y F. Hyaluronan-Directed Fabrication of Co - doped Hydroxyapatite as a Dual - Modal Probe for Tumor-Specific Bioimaging[J]. J. Mater. Chem. B, 2020,8:2107-2114. doi: 10.1039/C9TB02787D
10. [10]
  Sava Gallis D F, Rohwer L E S, Rodriguez M A, Barnhart-Dailey M C, Butler K S, Luk T S, Timlin J A, Chapman K W. Multifunctional, Tunable Metal - Organic Framework Materials Platform for Bioimaging Applications[J]. ACS Appl. Mater. Interfaces, 2017,9(27):22268-22277. doi: 10.1021/acsami.7b05859
11. [11]
  Zhu Y J, Guo Y J, Liu M D, Wei L B, Wang X T. An Oroxylin A - Loaded Aggregation - Induced Emission Active Polymeric System Greatly Increased the Antitumor Efficacy Against Squamous Cell Carcinoma[J]. J. Mater. Chem. B, 2020,8(10):2040-2047. doi: 10.1039/C9TB01818B
12. [12]
  Wang Z Y, Wang C, Gan Q, Cao Y, Yuan H, Hua D B. Donor-Acceptor-Type Conjugated Polymer - Based Multicolored Drug Carriers with Tunable Aggregation-Induced Emission Behavior for Self-Illuminat-ing Cancer Therapy[J]. ACS Appl. Mater. Interfaces, 2019,11(45):41853-41861. doi: 10.1021/acsami.9b11237
13. [13]
  Tsai W K, Chan Y H. Semiconducting Polymer Dots as Near - Infrared Fluorescent Probes for Bioimaging and Sensing[J]. J. Chin. Chem. Soc., 2019,66(1):9-20. doi: 10.1002/jccs.201800322
14. [14]
  Han L, Liu S G, Zhang X F, Tao B X, Li N B, Luo H Q. A Sensitive Polymer Dots-Manganese Dioxide Fluorescent Nanosensor for "Turn-On" Detection of Glutathione in Human Serum[J]. Sens. Actuators B, 2018,258:25-31. doi: 10.1016/j.snb.2017.11.056
15. [15]
  Chen H B, Fang X F, Jin Y, Hu X, Yin M, Men X J, Chen N, Fan C H, Chiu D, Wan Y Z, Wu C F. Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host - Guest Interactions, and Enhanced Drug/siRNA Delivery[J]. Small, 2018,14(21)1800239. doi: 10.1002/smll.201800239
16. [16]
  Fang X F, Ju B, Liu Z H, Wang F, Xi G, Sun Z Z, Chen H B, Sui C X, Wang M X, Wu C F. Compact Conjugated Polymer Dots with Covalently Incorporated Metalloporphyrins for Hypoxia Bioimaging[J]. ChemBioChem, 2019,20(4):521-525. doi: 10.1002/cbic.201800438
17. [17]
  Yu J B, Rong Y, Kuo C T, Zhou X H, Chiu D. Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine[J]. Anal. Chem., 2017,89(1):42-56. doi: 10.1021/acs.analchem.6b04672
18. [18]
  Zhang Z, Yuan Y, Liu Z H, Chen H B, Chen D D, Fang X F, Zheng J, Qin W P, Wu C F. Brightness Enhancement of Near - Infrared Semiconducting Polymer Dots for In Vivo Whole-Body Cell Tracking in Deep Organs[J]. ACS Appl. Mater. Interfaces, 2018,10(32):26928-26935. doi: 10.1021/acsami.8b08735
19. [19]
  Tsai W K, Wang C I, Liao C H, Yao C N, Kuo T J, Liu M H, Hsu C P, Lin S Y, Wu C Y, Pyle J, Chen J X, Chan Y H. Molecular Design of Near-Infrared Fluorescent Pdots for Tumor Targeting: Aggregation-Induced Emission versus Anti - aggregation - Caused Quenching[J]. Chem. Sci., 2019,10(1):198-207. doi: 10.1039/C8SC03510E
20. [20]
  Yuan Y, Hou W Y, Sun Z Z, Liu J, Ma N, Li X S, Yin S Y, Qin W P, Wu C F. Measuring Cellular Uptake of Polymer Dots for Quantitative Imaging and Photodynamic Therapy[J]. Anal. Chem., 2021,93(18):7071-7078. doi: 10.1021/acs.analchem.1c00548
21. [21]
  Yan L L, Zhang Y, Xu B, Tian W J. Fluorescent Nanoparticles Based on AIE Fluorogens for Bioimaging[J]. Nanoscale,, 2016,8(5):2471-2487. doi: 10.1039/C5NR05051K
22. [22]
  Zhang Y, Chen Y J, Li X, Zhang J B, Chen J L, Xu B, Fu X Q, Tian W J. Folic Acid - Functionalized AIE Pdots Based on Amphiphilic PCL - b - PEG for Targeted Cell Imaging[J]. Polym. Chem., 2014,5(12):3824-3830. doi: 10.1039/C4PY00075G
23. [23]
  Liu Y Z, Mao L C, Yang S J, Liu M Y, Huang H Y, Wen Y Q, Deng F J, Li Y X, Zhang X Y, Wei Y. Synthesis and Biological Imaging of Fluorescent Polymeric Nanoparticles with AIE Feature via the Combination of RAFT Polymerization and Post-polymerization Modifica-tion[J]. Dyes Pigm., 2018,158:79-87. doi: 10.1016/j.dyepig.2018.05.032
24. [24]
  Zhang X Q, Liu M Y, Yang B, Zhang X Y, Chi Z G, Liu S W, Xu J R, Wei Y. Cross-Linkable Aggregation Induced Emission Dye Based Red Fluorescent Organic Nanoparticles and Their Cell Imaging Applications[J]. Polym. Chem., 2013,4(19):5060-5064. doi: 10.1039/c3py00860f
25. [25]
  Li J C, Rao J H, Pu K Y. Recent Progress on Semiconducting Polymer Nanoparticles for Molecular Imaging and Cancer Phototherapy[J]. Biomaterials, 2018,155:217-235. doi: 10.1016/j.biomaterials.2017.11.025
26. [26]
  Palner M, Pu K, Shao S, Rao J H. Semiconducting Polymer Nanoparticles with Persistent Near - Infrared Luminescence Show Potential for In Vivo Optical Imaging[J]. Angew. Chem. Int. Ed., 2015,54(39):11477-11480. doi: 10.1002/anie.201502736
27. [27]
  GUAN X L, LI Z F, WANG L, LIU M N, WANG K L, YANG X Q, LI Y L, HU L L, ZHAO X L, LAI S J, LEI Z Q. Preparation of AIE Polymer Dots (Pdots) Based on Poly(N - vinyl - 2 - pyrrolidone) - Eu(Ⅲ) Complex and Dual-color Live Cell Imaging[J]. Acta Chim. Sinica, 2019,77(12):1268-1278.
28. [28]
  Guan X L, Lu B C, Jin Q J, Li Z F, Wang L, Wang K L, Lai S J, Lei Z Q. AIE-Active Fluorescent Nonconjugated Polymer Dots for Dual-Alternating-Color Live Cell Imaging[J]. Ind. Eng. Chem. Res., 2018,57(44):14889-14898. doi: 10.1021/acs.iecr.8b03776
29. [29]
  Guan W J, Zhou W J, Lu C, Tang B Z. Synthesis and Design of Aggregation - Induced Emission Surfactants: Direct Observation of Micelle Transitions and Microemulsion Droplets[J]. Angew. Chem. Int. Ed., 2015,54(50):15160-15164. doi: 10.1002/anie.201507236
30. [30]
  CAI Y, CHEN M Q, JI H N, HUANG X H, SHEN J. Synthesis and Spectroscopic Studies of Eu(Ⅲ) Complex with Poly(N-vinyl acetamide)[J]. Acta Polym. Sin., 2003,4(4):599-602.
31. [31]
  Cui G H, Bai Y, Li W L, Gao Z G, Chen S Y, Qiu N N, Satoh T, Kakuchi T, Duan Q. Synthesis and Characterization of Eu(Ⅲ)-Based Coordination Complexes of Modified D - Glucosamine and Poly(N - isopropylacrylamide)[J]. Opt. Mater., 2017,72:115-121. doi: 10.1016/j.optmat.2017.05.051
32. [32]
  Sabbatini L, Malitesta C, Giglio E, Losito I, Torsi L, Zambonin P. Electrosynthesised Thin Polymer Films: The Role of XPS in the Design of Application Oriented Innovative Materials[J]. J. Electron. Spectrosc. Relat. Phenom., 1999,100(1):35-53.
33. [33]
  Wang Y J, Jiang H L. Eu(Ⅲ) Modifies the Properties of Poly(N-isopro-pylacrylamide)[J]. Mater. Lett., 2007,61(13):2779-2782. doi: 10.1016/j.matlet.2006.10.055
34. [34]
  Zhong W B, Zeng X Y, Chen J, Hong Y X, Xiao L H, Zhang P S. Photoswitchable Fluorescent Polymeric Nanoparticles for Rewritable Fluorescence Patterning and Intracellular Dual - Color Imaging with AIE-based Fluorogens as FRET Donors[J]. Polym. Chem., 2017,8(33):4849-4855. doi: 10.1039/C7PY00834A
35. [35]
  Zhou P, Li G Y, Shao Z Z, Pan X Y, Yu T Y. Structure of Bombyx Mori Silk Fibroin Based on the DFT Chemical Shift Calculation[J]. J. Phys. Chem. B, 2001,105(50):12469-12376. doi: 10.1021/jp0125395
36. [36]
  Grüll H, Langereis S. Hyperthermia - Triggered Drug Delivery from Temperature-Sensitive Liposomes Using MRI-Guided High Intensity Focused Ultrasound[J]. J. Control. Release, 2012,161(2):317-327. doi: 10.1016/j.jconrel.2012.04.041
37. [37]
  Wang W, Gao C Q, Qu Y Q, Song Z F, Zhang W Q. In Situ Synthesis of Thermoresponsive Polystyrene- b-poly(N -isopropylacrylamide)-b-polystyrene Nanospheres and Comparative Study of the Looped and Linear Poly(N - isopropylacrylamide)s[J]. Macromolecules, 2016,49(7):2772-2781. doi: 10.1021/acs.macromol.6b00233
38. [38]
  Adelsberger J, Kulkarni A, Jain A, Wang W N, Bivigou-Koumba A, Busch P, Pipich V, Holderer O, Hellweg T, Laschewsky A, Müller-Buschbaum P, Papadakis C. Thermoresponsive PS-b-PNIPAM-b-PS Micelles: Aggregation Behavior, Segmental Dynamics, and Thermal Response[J]. Macromolecules, 2010,43(5):2490-2501. doi: 10.1021/ma902714p
39. [39]
  Sun L N, Yu J B, Peng H S, Zhang J Z, Shi L Y, Wolfbeis O S. Temperature-Sensitive Luminescent Nanoparticles and Films Based on a Terbium Complex Probe[J]. J. Phys. Chem. C, 2010,114(29):12642-12648. doi: 10.1021/jp1028323
40. [40]
  Ge X Q, Sun L N, Dang S, Liu J L, Xu Y X, Wei Z W, Shi L Y, Zhang H J. Mesoporous Upconversion Nanoparticles Modified with a Tb Complex to Display both Green Upconversion and Downcon-version Luminescence for In Vitro Bioimaging and Sensing of Tem-perature[J]. Microchim. Acta, 2015,182:1653-1660. doi: 10.1007/s00604-015-1481-0
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