Citation: Oladeji S. Olatunde, Ikhile I. Monisola, Mamo Messai, Ndungu G. Patrick, Ndinteh T. Derek. Synthesis, Characterization and Antimicrobial Screening of Various Ferrocenyl Schiff Bases against Gram-positive and Gram-negative Bacteria[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(4): 705-715. doi: 10.11862/CJIC.2022.065 shu

Synthesis, Characterization and Antimicrobial Screening of Various Ferrocenyl Schiff Bases against Gram-positive and Gram-negative Bacteria

Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg, South Africa

Corresponding author: Ikhile I. Monisola, miikhile@gmail.com Ndinteh T. Derek, dndinteh@uj.ac.za
Received Date: 10 May 2021
Revised Date: 24 November 2021

Figures(4)

Ten ferrocenyl Schiff bases 1-10 were synthesized and characterized using UV-Vis spectroscopy, FT-IR, elemental analysis, ¹H and ¹³C NMR spectroscopy. The synthesized compounds were evaluated against 11 bacteria strains (Bacillus subtilis ATCC19659, Klebsiella aerogenes ATCC13882, Enterococcus faecalis ATCC13047, Myco- bacterium smegmatis MC2155, Staphylococcus epidermidis ATCC14990, Staphylococcus aureus ATCC25923, Esche-richia coli ATCC25922, Enterobacter cloacae ATCC13047, Klebsiella oxytoca ATCC8724, Proteus mirabilis ATCC7002, Proteus vulgaris ATCC6380). The results obtained from antibacterial assay indicated that the synthe- sized Schiff bases 1-10 inhibited potential growth of Klebsiella aerogenes with the minimum inhibitory concentration (MIC) ranging from 15.6 to 31.25 μg·mL^-1 and Enterococcus faecalis with MIC the range between 31.25 and 125 μg· mL^-1 in comparison with the standard nalidixic acid and streptomycin sulfate.
- antibacterial,
- Schiff bases,
- nalidixic,
- synthesis,
- inhibition
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