Citation: Li-Ping ZHANG, Yong-Gang WAN, Yan-Min WU, Jie WANG, Dong-Bin XU, Jian-Lei XUE, Wen-Bo DUAN, Dao-Sen LIU. One-Pot Aqueous Synthesis and Cell Labeling Application of Glutathione Capped Cu-In-Zn-S Quantum Dots[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(2): 361-367. doi: 10.11862/CJIC.2022.003 shu

One-Pot Aqueous Synthesis and Cell Labeling Application of Glutathione Capped Cu-In-Zn-S Quantum Dots

1.
College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China
2.
Communication and Electronic Engineering Institute, Qiqihar University, Qiqihar, Heilongjiang 161006, China

Corresponding author: Li-Ping ZHANG, zhangliping@qmu.edu.cn
Received Date: 11 June 2021
Revised Date: 27 September 2021

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We report a one-pot method to directly synthesize highly luminescent Cu-n-Zn-S (CIZS) quantum dots (QDs) in aqueous media by using bio-compatible glutathione (GSH) as capping ligand and stabilizer. The influences of various experimental variables, including reaction time, pH value, and precursor ratio, have been systematically investigated. The optical features and structure of the obtained CIZS QDs have been characterized by UV-Vis and fluorescence spectroscopy, transmission electron microscope, powder X-ray diffraction, and FT-IR. As a result, the stable GSH capped CIZS QDs exhibited excellent photoluminescence emission properties, narrow size distribution and excellent biocompatibility under optimum experimental conditions. In addition, as-prepared CIZS QDs were successfully used for fluorescence imaging of MDA-MB-231 cells and emitted bright red fluorescence.
- hydrophilic synthesis,
- Cu-In-Zn-S quantum dots,
- glutathione capped,
- photoluminescence
1. [1]
  Alivisatos A P. Semiconductor Clusters, Nanocrystals, and Quantum Dots[J]. Science, 1996,271:933-937. doi: 10.1126/science.271.5251.933
2. [2]
  Peng X G, Manna L, Yang W D, Wickham J, Scher E, Kadavanich A, Alivisatos A P. Shape Control of CdSe Nanocrystals[J]. Nature, 2000,404:59-61. doi: 10.1038/35003535
3. [3]
  Xi L L, Ma H B, Tao G H. Thiourea Functionalized CdSe/CdS Quantum Dots as a Fluorescent Sensor for Mercury Ion Detection[J]. Chin. Chem. Lett., 2016,27(9):1531-1536. doi: 10.1016/j.cclet.2016.03.002
4. [4]
  Kim D, Kim D H, Lee J H, Grossman J C. Impact of Stoichiometry on the Electronic Structure of PbS Quantum Dots[J]. Phys. Rev. Lett., 2013,110196802. doi: 10.1103/PhysRevLett.110.196802
5. [5]
  Wang G F, Guan A X, Zhou C Y, Xia S Y, Chen Q, Chen X T, Zhou L Y. Luminescence Properties of CdTe QDs Embedded in Zn₅(CO₃)₂(OH)₆ Matrix[J]. Chin. Chem. Lett., 2016,27(12):1788-1792. doi: 10.1016/j.cclet.2016.07.012
6. [6]
  Derfus A M, Chan W C W, Bhatia S N. Probing the Cytotoxicity of Semiconductor Quantum Dots[J]. Nano Lett., 2004,4(1):11-18. doi: 10.1021/nl0347334
7. [7]
  Lai L, Jin J C, Xu Z Q, Ge Y S, Jiang F L, Liu Y. Spectroscopic and Microscopic Studies on the Mechanism of Mitochondrial Toxicity Induced by CdTe QDs Modified with Different Ligands[J]. J. Membr. Biol., 2015,248(4):727-740. doi: 10.1007/s00232-015-9785-x
8. [8]
  Zhang L J, Yu H F, Cao W, Zou C, Dong Y Q, Zhu D M, Huang S M. Enhanced Electrical and Optoelectrical Properties of Cadmium Selenide Nanobelts by Chlorine Doping[J]. Micro Nano Lett., 2014,9(1):55-59. doi: 10.1049/mnl.2013.0611
9. [9]
  Lan Y W, Yang K, Wang Y L, Li H M. Aqueous Synthesis of Highly Luminescent CdSe Quantum Dots with Narrow Spectra Using Hydrazine Hydrate Reduction Selenium[J]. Micro Nano Lett., 2014,9(3):202-205. doi: 10.1049/mnl.2013.0608
10. [10]
  Deng D W, Qu L Z, Zhang J, Ma Y X, Gu Y Q. Quaternary Zn-Ag-In-Se Quantum Dots for Biomedical Optical Imaging of RGD-Modified Micelles[J]. ACS Appl. Mater. Interfaces, 2013,5(21):10858-10865. doi: 10.1021/am403050s
11. [11]
  Kong W G, Zhang B P, Li R F, Wu F F, XuT N, Wu H Z. Plasmon Enhanced Fluorescence from Quaternary Cu-In-Zn-S Quantum Dots[J]. Appl. Surf. Sci., 2015,327(1):394-399.
12. [12]
  Wang Y, Hu Y X, Zhang Q, Ge J P, Lu Z D, Hou Y B, Yin Y D. One-Pot Synthesis and Optical Property of Copper Sulfide Nanodisks[J]. Inorg. Chem., 2010,49(14):6601-6608. doi: 10.1021/ic100473e
13. [13]
  Saldanha P L, Brescia R, Prato M, Li H B, Povia M, Manna L, Lesnyak V. Generalized One-Pot Synthesis of Copper Sulfide, Selenide-Sulfide, and Telluride-Sulfide Nanoparticles[J]. Chem. Mater., 2014,26(3):1442-1449. doi: 10.1021/cm4035598
14. [14]
  Torimoto T, Adachi T, Okazaki K I, Sakuraoka M, Shibayama T, Ohtani B, Kudo A, Kuwabata S. Facile Synthesis of ZnS-AgInS₂ Solid Solution Nanoparticles for a Color-Adjustable Luminophore[J]. J. Am. Chem. Soc., 2007,129(41):12388-12389. doi: 10.1021/ja0750470
15. [15]
  Aldakov D, Lefrancois A, Reiss P. Ternary and Quaternary Metal Chalcogenide Nanocrystals: Synthesis, Properties and Applications[J]. J. Mater. Chem. C, 2013,1(24):3756-3776. doi: 10.1039/c3tc30273c
16. [16]
  Yarema O, Bozyigit D, Rousseau I, Nowack L, Yarema M, Heiss W, Wood V. Highly Luminescent, Size - and Shape-Tunable Copper Indium Selenide Based Colloidal Nanocrystals[J]. Chem. Mater., 2013,25(18):3753-3757. doi: 10.1021/cm402306q
17. [17]
  Xiang W D, Ma X, Luo L, Cai W, Xie C P, Liang X J. Facile Synthesis and Characterization of Core/Shell Cu-In-Zn-S/ZnS Nanocrystals with High Luminescence[J]. Mater. Chem. Phys., 2015,149-150:437-444. doi: 10.1016/j.matchemphys.2014.10.042
18. [18]
  Nakamura H, Kato W, Uehara M, Nose K, Omata T, Matsuo S O Y, Miyazaki M, Maeda H. Tunable Photoluminescence Wavelength of Chalcopyrite CuInS₂-Based Semiconductor Nanocrystals Synthesized in a Colloidal System[J]. Chem. Mater., 2006,18(14):3330-3335. doi: 10.1021/cm0518022
19. [19]
  Liu W Y, Zhang Y, Zhai W W, Wang Y H, Zhang T Q, Gu P F, Chu H R, Zhang H Z, Cui T, Wang Y D, Zhao J, Yu W W. Temperature-Dependent Photoluminescence of ZnCuInS/ZnSe/ZnS Quantum Dots[J]. J. Phys. Chem. C, 2013,117(38):19288-19294.
20. [20]
  Zhang W J, Zhong X H. Facile Synthesis of ZnS-CuInS₂-Alloyed Nanocrystals for a Color-Tunable Fluorchrome and Photocatalyst[J]. Inorg. Chem., 2011,50(9):4065-4072. doi: 10.1021/ic102559e
21. [21]
  Ding L, Zhou P J, Zhan H J, Chen C, Hu W, Zhou T F, Lin C W. Microwave-Assisted Synthesis of L-Glutathione capped ZnSe QDs and Its Interaction with BSA by Spectroscopy[J]. J. Lumin., 2013,142:167-172. doi: 10.1016/j.jlumin.2013.04.008
22. [22]
  Zheng Y, Gao S, Ying J Y. Synthesis and Cell-Imaging Applications of Glutathione-Capped CdTe Quantum Dots[J]. Adv. Mater., 2007,19(3):376-380. doi: 10.1002/adma.200600342
23. [23]
  Leng Z S, Huang L, Shao F, Lv Z C, Li T T, Gu X X, Han H Y. Facile Synthesis of Cu-In-Zn-S Alloyed Nanocrystals with Temperature-Dependent Photoluminescence Spectra[J]. Mater. Lett., 2014,119:100-103. doi: 10.1016/j.matlet.2013.12.109
24. [24]
  Mao W Y, Guo J, Yang W L, Wang C C, He J, Chen J Y. Synthesis of High-Quality Near-Infrared-Emitting CdTeS Alloyed Quantum Dots via the Hydrothermal Method[J]. Nanotechnology, 2007,18(48)485611. doi: 10.1088/0957-4484/18/48/485611
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沈阳化工大学材料科学与工程学院沈阳 110142