Citation: Pei-Pei QIAO, Yue-Wei TIAN, Qing HE, Yong-Po ZHANG, Chun-Yan GAO, Jin-Zhong ZHAO, Wei-Jun DU. Synthesis, Structure and Anticancer Activity of Binuclear Polypyridine Nickel Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(10): 1738-1744. doi: 10.11862/CJIC.2021.207 shu

Synthesis, Structure and Anticancer Activity of Binuclear Polypyridine Nickel Complexes

1.
Department of Basic Sciences, Shanxi Agricultural University, Jinzhong, Shanxi 030801, China
2.
College of Agronomy, Shanxi Agricultural University, Jinzhong, Shanxi 030801, China

Corresponding author: Chun-Yan GAO, gaocynk@163.com Wei-Jun DU, duweijun68@126.com
Received Date: 2 February 2021
Revised Date: 16 July 2021

Figures(5)

Two new polypyridine dinuclear nickel (Ⅱ) complexes[Ni₂(L)₂Cl₂](ClO₄)₂·3H₂O (1) and[Ni₂(L)₂Cl₂](PF₆)₂ (2) (L=N, N-bis(pyridin-2-ylmethyl)-4-(4-((pyridin-2-ylmethyl)amino)benzyl)aniline) were synthesized, and their structures were determined by X-ray single crystal diffraction, elemental analysis and infrared spectroscopy. Moreover, the in vitro toxic effects of the two complexes on cancer cells (HeLa, BGC-823, NCI-H460, HepG-2) were tested by thiazole blue (MTT) method, and the results indicate that the two complexes showed good toxicity on NCIH460 cells. IC₅₀=(26.0±2.2) μmol·L^-1 (1), (31.3±2.7) μmol·L^-1 (2). The cytotoxic mechanism of complex 1 towards NCI-H460 cells was further explored by Hoechst 33342 staining, detection of intracellular reactive oxygen species levels and measurement of mitochondrial membrane potential change. The results demonstrate that complex 1 is likely to induce cell apoptosis through the mitochondrial pathway, thereby causing lethal effects on cancer cells.
- nickel complex,
- crystal structure,
- cytotoxicity,
- mitochondrial pathway
1. [1]
  Farrell N, Spinelli S. Uses of Inorganic Chemistry in Medicine. Cambridge: RSC, 1999: 124-134
2. [2]
  Johnstone T C, Suntharalingam K, Lippard S J. Chem. Rev., 2016, 116(5): 3436-3486 doi: 10.1021/acs.chemrev.5b00597
3. [3]
  JIN S X, GUO Z J, WANG X Y. Progress in Pharmaceutical Sciences, 2020, 44(4): 280-293
4. [4]
  Galluzzi L, Vitale I, Michels J, Brenner C, Szabadkai G, Harel-Bellan A, Castedo M, Kroemer G. Cell Death Dis., 2014, 5(5): e1257
5. [5]
  MO H W, LIU Y X, CAI D H, SHEN F, LE X Y. Chinese J. Inorg. Chem., 2019, 35(3): 477-484
6. [6]
  Zhang P L, Hou X X, Liu M R, Huang F P, Qin X Y. Dalton Trans., 2020, 49: 6043-6055 doi: 10.1039/D0DT00380H
7. [7]
  Zhao Y, Li Z, Li H, Wang S, Niu M. Inorg. Chim. Acta, 2018, 482: 136-143 doi: 10.1016/j.ica.2018.06.008
8. [8]
  Walsh C T, Orme-Johnson W H. Biochemistry, 1987, 26(16): 4901-4906 doi: 10.1021/bi00390a001
9. [9]
  Ramasubramanian R, Anandababu K, Kumar M, Mayilmurugan R. Dalton Trans., 2018, 47(12): 4049-4053 doi: 10.1039/C7DT04739H
10. [10]
  Saylor Z, Maier R. Microbiology, 2018, 164(8): 1059-1068 doi: 10.1099/mic.0.000680
11. [11]
  Su X, Mccardle K M, Panetier J A, Jurss J W. Chem. Commun., 2018, 54: 3351-3354 doi: 10.1039/C8CC00266E
12. [12]
  Pang H, Lu Q, Li Y, Gao F. Chem. Commun., 2009, 48(48): 7542-7544
13. [13]
  Campo R, Criado J J, García E, Hermosa M R, Jiménez-Sánchez A, Manzano J L, Monte E, Rodríguez-Fernández E, Sanz F. J. Inorg. Biochem., 2002, 89(1/2): 74-82
14. [14]
  ZHANG Y P, LÜ J Y, WANG Y F, GAO C Y, ZHAO J Z. Acta Scientiarum Naturallum Universitatis Nankaiensis, 2016, 49(2): 77-83
15. [15]
  Gao C Y, Ma Z Y, Zhang Y P, Li S T, Gu W, Liu X, Tian J L, Xu J Y, Zhao J Z, Yan S P. RSC Adv., 2015, 5(39): 30768-30779 doi: 10.1039/C4RA16755D
16. [16]
  PAN J B, CHEN X, FANG W J, LIU W, YU G W. Chinese J. Inorg. Chem., 2018, 34(5): 889-896
17. [17]
  Fujita M. Chem. Soc. Rev., 1998, 27(6): 417-425 doi: 10.1039/a827417z
18. [18]
  Olenyuk B, Fechtenkötter A, Stang P J. J. Chem. Soc. Dalton Trans., 1998(11): 1707-1728 doi: 10.1039/a801057i
19. [19]
  Wang F Y, Xi Q Y, Huang K B, Tang X M, Chen Z F, Liu Y C, Liang H. J. Inorg. Biochem., 2017, 169: 23-31 doi: 10.1016/j.jinorgbio.2017.01.001
20. [20]
  Icsel C, Yilmaz V T, Aydinlik S, Aygun M. Dalton Trans., 2020, 49(23): 7842-7851 doi: 10.1039/D0DT01535K
21. [21]
  Gao C Y, Qiao X, Ma Z Y, Wang Z G, Lu J, Tian J L, Xu J Y, Yan S P. Dalton Trans., 2012, 41(39): 12220-12232 doi: 10.1039/c2dt31306e
22. [22]
  Sheldrick G M. Correction Software, University of Göttingen, Germany, 1996.
23. [23]
  Sheldrick G M. SHELXS-97, Program for the Solution of Crystal Structure, University of Göttingen, Germany, 1997.
24. [24]
  Sheldrick G M. SHELXL-97, Program for the Refinement of Crystal Structure, University of Göttingen, Germany, 1997.
25. [25]
  Feng C, Gan Q, Liu X, He H. Chin. J. Chem., 2012, 30(7): 1589-1593 doi: 10.1002/cjoc.201100744
26. [26]
  Wan D, Lai S H, Zeng C C, Zhang C, Tang B, Liu Y J. J. Inorg. Biochem., 2017, 173: 1-11 doi: 10.1016/j.jinorgbio.2017.04.026
27. [27]
  Yue X L, Lehri S, Li P, Barbier-Chassefière V, Petit E, Huang Q F, Albanese P, Barritault D, Caruelle J P, Papy-Garcia D, Morin C. Cell Death Differ., 2009, 16(5): 770-781 doi: 10.1038/cdd.2009.9
28. [28]
  Green D R, Kroemer G. Science, 2004, 305(5684): 626-629 doi: 10.1126/science.1099320
1. [1]
  Keweiyang Zhang , Zihan Fan , Liyuan Xiao , Haitao Long , Jing Jing . Unveiling Crystal Field Theory: Preparation, Characterization, and Performance Assessment of Nickel Macrocyclic Complexes. University Chemistry, 2024, 39(5): 163-171. doi: 10.3866/PKU.DXHX202310084
2. [2]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
3. [3]
  Changqing MIAO , Fengjiao CHEN , Wenyu LI , Shujie WEI , Yuqing YAO , Keyi WANG , Ni WANG , Xiaoyan XIN , Ming FANG . Crystal structures, DNA action, and antibacterial activities of three tetranuclear lanthanide-based complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2455-2465. doi: 10.11862/CJIC.20240192
4. [4]
  Jing WU , Puzhen HUI , Huilin ZHENG , Pingchuan YUAN , Chunfei WANG , Hui WANG , Xiaoxia GU . Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278
5. [5]
  Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
6. [6]
  Jingjing QING , Fan HE , Zhihui LIU , Shuaipeng HOU , Ya LIU , Yifan JIANG , Mengting TAN , Lifang HE , Fuxing ZHANG , Xiaoming ZHU . Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1301-1308. doi: 10.11862/CJIC.20240003
7. [7]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
8. [8]
  Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
9. [9]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
10. [10]
  Yan Liu , Yuexiang Zhu , Luhua Lai . Introduction to Blended and Small-Class Teaching in Structural Chemistry: Exploring the Structure and Properties of Crystals. University Chemistry, 2024, 39(3): 1-4. doi: 10.3866/PKU.DXHX202306084
11. [11]
  Weina Wang , Fengyi Liu , Wenliang Wang . “Extracting Commonality, Delving into Typicals, Deriving Individuality”: Constructing a Knowledge Graph of Crystal Structures. University Chemistry, 2024, 39(3): 36-42. doi: 10.3866/PKU.DXHX202308029
12. [12]
  Junqiao Zhuo , Xinchen Huang , Qi Wang . Symbol Representation of the Packing-Filling Model of the Crystal Structure and Its Application. University Chemistry, 2024, 39(3): 70-77. doi: 10.3866/PKU.DXHX202311100
13. [13]
  Wenyan Dan , Weijie Li , Xiaogang Wang . The Technical Analysis of Visual Software ShelXle for Refinement of Small Molecular Crystal Structure. University Chemistry, 2024, 39(3): 63-69. doi: 10.3866/PKU.DXHX202302060
14. [14]
  Linjie ZHU , Xufeng LIU . Electrocatalytic hydrogen evolution performance of tetra-iron complexes with bridging diphosphine ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 321-328. doi: 10.11862/CJIC.20240207
15. [15]
  Jinfeng Chu , Lan Jin , Yu-Fei Song . Exploration and Practice of Flipped Classroom in Inorganic Chemistry Experiment: a Case Study on the Preparation of Inorganic Crystalline Compounds. University Chemistry, 2024, 39(2): 248-254. doi: 10.3866/PKU.DXHX202308016
16. [16]
  Xiaoling LUO , Pintian ZOU , Xiaoyan WANG , Zheng LIU , Xiangfei KONG , Qun TANG , Sheng WANG . Synthesis, crystal structures, and properties of lanthanide metal-organic frameworks based on 2, 5-dibromoterephthalic acid ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1143-1150. doi: 10.11862/CJIC.20230271
17. [17]
  Yuyao Wang , Zhitao Cao , Zeyu Du , Xinxin Cao , Shuquan Liang . Research Progress of Iron-based Polyanionic Cathode Materials for Sodium-Ion Batteries. Acta Physico-Chimica Sinica, 2025, 41(4): 100035-. doi: 10.3866/PKU.WHXB202406014
18. [18]
  Yongzhi LI , Han ZHANG , Gangding WANG , Yanwei SUI , Lei HOU , Yaoyu WANG . A two-dimensional metal-organic framework for the determination of nitrofurantoin and nitrofurazone in aqueous solution. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 245-253. doi: 10.11862/CJIC.20240307
19. [19]
  Zhaoyang WANG , Chun YANG , Yaoyao Song , Na HAN , Xiaomeng LIU , Qinglun WANG . Lanthanide(Ⅲ) complexes derived from 4′-(2-pyridyl)-2, 2′∶6′, 2″-terpyridine: Crystal structures, fluorescent and magnetic properties. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1442-1451. doi: 10.11862/CJIC.20240114
20. [20]
  Jing JIN , Zhuming GUO , Zhiyin XIAO , Xiujuan JIANG , Yi HE , Xiaoming LIU . Tuning the stability and cytotoxicity of fac-[Fe(CO)₃I₃]^- anion by its counter ions: From aminiums to inorganic cations. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 991-1004. doi: 10.11862/CJIC.20230458

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(1179)
HTML views(326)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142