Citation: Li-Ning YANG, Chun-Ye LIU, Zhao CHENG, Ling-Ling LIANG, Jian ZHANG. Synthesis, Crystal Structure and Biological Activity of Cu(Ⅱ) and Ag(Ⅰ) Complexes Involving Nitroimidazole Derivative[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(9): 1547-1554. doi: 10.11862/CJIC.2021.186 shu

Synthesis, Crystal Structure and Biological Activity of Cu(Ⅱ) and Ag(Ⅰ) Complexes Involving Nitroimidazole Derivative

Department of Pharmacy, Medical University of Xi'an, Xi'an 710021, China

Corresponding author: Li-Ning YANG, zyfyln828@163.com
Received Date: 27 January 2021
Revised Date: 25 May 2021

Figures(11)

The copper(Ⅱ) and silver(Ⅰ) complexes[Cu(L)(Ac)₂]₂ (1), [Ag(L)(NO₃)]·H₂O (2) (L=N, N'-dimethyl-5-nitro-2, 2'-biimidazole) has been synthesized. X-ray crystallographic study was used to determine the crystallographic structure of complex 1, which exhibits a five-coordinated dimeric copper-acetato paddle-wheel geometry. Complex 2 was characterized by elemental analysis, UV-Vis, FT-IR, solid fluorescence spectra, thermogravimetric analysis, ESI-MS and conductivity analysis. The structure of complex 2 probably was a two-coordinated mononuclear structural unit of linear configuration. The binding property of L and complexes toward calf thymus DNA (ct-DNA) was figured out via electronic absorption, fluorescence spectra and viscosity measurements. Complex 1 revealed slightly stronger DNA binding capability than 2 and ligand. The antianaerobe activities of L and its complexes were tested by two-fold agar dilution method. The results showed that L displayed favorable activity of anti-anaerobic bacteria against Actinobacillus actinomycetem (ATCC 29523) selectively with minimum inhibitory concentrations of 0.625~1.25 μg·mL^-1, even better than the classical anti-anaerobic drug metronidazole.
- nitroimidazole derivative,
- metal complex,
- crystal structure,
- DNA interaction,
- anti-anaerobic activity
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