Citation: Qing-Tao CHEN, Xiang-Dong SHI, Wei-Wei LIANG, Li-Ying JIANG, Shao-Ming FANG, Feng-Hua CHEN. Synthesis of Fluorescence/MRI Dual Targeted Imaging Theranostics Reagent[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(9): 1555-1562. doi: 10.11862/CJIC.2021.181 shu

Synthesis of Fluorescence/MRI Dual Targeted Imaging Theranostics Reagent

1.
College of Materials and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China
2.
College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China

Corresponding author: Feng-Hua CHEN, phenix@zzuli.edu.cn
Received Date: 21 February 2021
Revised Date: 21 May 2021

Figures(10)

Poly (ethylene glycol diamine) (NH₂-PEG-NH₂) modified graphene quantum dots (GODs) were conjugated with diethylenetriaminepentaacetic acid (DTPA) via an amide bond. Then the product further coordinated with Gd³⁺ ions, followed by the subsequent linkage of folic acid (FA) to form FA/GODs-Gd(DTPA). Next, an anticancer drug, doxorubicin (DOX), was loaded on the surface of FA/GODs-Gd(DTPA) to obtain the final fluorescence/MRI dual targeted imaging diagnostic reagents (FA/GODs-Gd(DTPA)/DOX) for lung cancer cells. The sample was characterized by transmission electron microscopy, UV-Vis absorption spectroscopy, fluorescence spectroscopy, laser confocal microscopy, and so on. Compared with normal HLF cells, the results of MRI, confocal laser scanning microscopy and MTT showed that the prepared FA/GODs-Gd(DTPA)/DOX could be targeted to detect lung cancer H460 cells, in which folate receptor was highly expressed, and also displayed significant anti-tumor activity.
- graphene quantum dots,
- fluorescence,
- magnetic resonance imaging,
- nanoparticles,
- theranostics
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沈阳化工大学材料科学与工程学院沈阳 110142