Citation: Li ZHANG, Lin-Feng GUO, Sheng HUANG, Jie KANG, Wei-Ming SUN. Synthesis, Characterization and Biological Activity of Pr(Ⅲ) Complex Constructed by Pyridine-2,6-dicarboxylate[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(7): 1269-1276. doi: 10.11862/CJIC.2021.139 shu

Synthesis, Characterization and Biological Activity of Pr(Ⅲ) Complex Constructed by Pyridine-2,6-dicarboxylate

Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350108, China

Corresponding author: Jie KANG, davidkj660825@163.com Wei-Ming SUN, sunwm@fjmu.edu.cn
Received Date: 14 December 2020
Revised Date: 30 April 2021

Figures(4)

A novel Pr(Ⅲ)-based co-crystal complex, (H₂pipz)_1.5[Pr(pdc)3]·7H₂O (1, pdc^2-=pyridine-2,6-dicarboxylate and pipz=piperazine) has been synthesized under hydrothermal condition. Infrared (IR) spectroscopy, elemental analysis, and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure of complex 1. To deeply reveal the electronic structure of complex 1, density functional theory (DFT) calculations were employed to investigate the electrostatic potential (ESP) and frontier molecular orbitals (FMO) of the structural unit [Pr(pdc)₃]^3-. More importantly, the antitumor test showed that complex 1 exhibited good cytotoxic activity against K562 (IC₅₀=(61.3±10.2) μg·mL^-1) and OE-19 cells (IC₅₀=(15.9±3.2) μg·mL^-1), especially more effective against OE-19 cells. CCDC: 1834053.
- praseodymium(Ⅲ) complex,
- crystal structure,
- antitumor activity,
- theoretical calculation
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