Citation:
Qun-Ying YU. Symmetrical Diruthenium(Ⅱ) Complex Based on 1-Isopropyl-4-methylbenzene and Dimethylbiguanide: Synthesis and Anticancer Activity in Vitro[J]. Chinese Journal of Inorganic Chemistry,
;2021, 37(5): 899-904.
doi:
10.11862/CJIC.2021.093
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A novel symmetrical dinuclear bridging complex (NH4)2[Ru(Cym)(L)]2Cl2·4H2O (1) (Cym=p-cymene=1-isopropyl-4-methylbenzene, H2L=1, 1-dimethylbiguanide) was obtained by treatment of the precursor[Ru(Cym)Cl2]2 with metformin hydrochloride. In aqueous base solution, deprotonation of the proligand (1, 1-dimethylbiguanide) occured and the corresponding neutral ruthenium complex 1 was obtained. The structure of complex 1 has been established by FT-IR and NMR spectroscopy and single-crystal X-ray diffraction analysis. The number of crystal water was obtained by thermogravimetric analysis. The inhibition of cell proliferation activity against four human cancer cell lines (HepG-2, A549, Hela, MCF-7) of complex 1 relative to cisplatin was measured by MTT method in vitro. Notably, the novel complex displayed comparable potency toward HepG-2 (hepatocellular carcinoma, HCC) compared to cisplatin.
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Keywords:
- ruthenium complex,
- crystal structure,
- anticancer activity,
- cisplatin
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