Citation: Qun-Ying YU. Symmetrical Diruthenium(Ⅱ) Complex Based on 1-Isopropyl-4-methylbenzene and Dimethylbiguanide: Synthesis and Anticancer Activity in Vitro[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(5): 899-904. doi: 10.11862/CJIC.2021.093 shu

Symmetrical Diruthenium(Ⅱ) Complex Based on 1-Isopropyl-4-methylbenzene and Dimethylbiguanide: Synthesis and Anticancer Activity in Vitro

Qun-Ying YU

School of Pharmacy and Life Science, Jiujiang University, Jiujiang, Jiangxi 332000, China

Received Date: 27 September 2020
Revised Date: 14 March 2021

Figures(5)

A novel symmetrical dinuclear bridging complex (NH₄)₂[Ru(Cym)(L)]₂Cl₂·4H₂O (1) (Cym=p-cymene=1-isopropyl-4-methylbenzene, H₂L=1, 1-dimethylbiguanide) was obtained by treatment of the precursor[Ru(Cym)Cl₂]₂ with metformin hydrochloride. In aqueous base solution, deprotonation of the proligand (1, 1-dimethylbiguanide) occured and the corresponding neutral ruthenium complex 1 was obtained. The structure of complex 1 has been established by FT-IR and NMR spectroscopy and single-crystal X-ray diffraction analysis. The number of crystal water was obtained by thermogravimetric analysis. The inhibition of cell proliferation activity against four human cancer cell lines (HepG-2, A549, Hela, MCF-7) of complex 1 relative to cisplatin was measured by MTT method in vitro. Notably, the novel complex displayed comparable potency toward HepG-2 (hepatocellular carcinoma, HCC) compared to cisplatin.
- ruthenium complex,
- crystal structure,
- anticancer activity,
- cisplatin
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