Citation: Xian-Tao JIANG, Xiao-Hui WANG, Pei-Yuan LI, Wei SU. Synthesis, Structure and Photoactivated Anticancer Activity of Ruthenium-Arene Complexes with Curcuminoids[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(3): 431-436. doi: 10.11862/CJIC.2021.047 shu

Synthesis, Structure and Photoactivated Anticancer Activity of Ruthenium-Arene Complexes with Curcuminoids

1.
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530001, China
2.
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530001, China

Corresponding author: Pei-Yuan LI, lipearpear@163.com Wei SU, suwmail@163.com
Received Date: 15 June 2020
Revised Date: 1 November 2020

Figures(5)

Three ruthenium-arene complexes with curcuminoids (1~3) were synthesized through the reaction of[(η⁶-p-cymene)RuCl₂]₂ and the corresponding curcuminoids derivative (L¹~L³) followed by the reaction with 1, 3, 5-tiaza-7-phosphaadamantane (PTA). The complexes were structurally characterized by single crystal XRD, ¹H NMR, MS and elemental analysis. The inhibitory activities of the complexes towards HepG2 human liver cancer cell lines were investigated by MTT with light (λ>400 nm). The results show that three complexes present half-sandwich structure. Anticancer activity of the complexes was significantly improved by light, among which the IC₅₀ of complex 3 decreased from (60.3±1.1) μmol·L^-1 to (45.0±6.1) μmol·L^-1 against HepG2, indicating that light can effectively improve the anticancer activity of this kind of complexes. CCDC: 1514601, 1; 1514600, 2; 1514603, 3.
- ruthenium-arene complexes,
- curcuminoids,
- anticancer activity,
- crystal structure
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沈阳化工大学材料科学与工程学院沈阳 110142