Citation: LI Tian-Le, ZHONG Hui, LI Xiao-Rong, ZHOU Jing, LIU Yi-Xin, HU Wei-Cheng, CHENG Zhi-Peng, YAO Cheng. Preparation and in Vitro Experiment of Attapulgite-based Microgels with Magnetic/Temperature Dual Sensitivities[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(1): 180-188. doi: 10.11862/CJIC.2021.017 shu

Preparation and in Vitro Experiment of Attapulgite-based Microgels with Magnetic/Temperature Dual Sensitivities

LI Tian-Le ^1,2 ,
ZHONG Hui ^1,2,, ,
LI Xiao-Rong ^2,, ,
ZHOU Jing ^3,4 ,
LIU Yi-Xin ² ,
HU Wei-Cheng ⁴ ,
CHENG Zhi-Peng ² ,
YAO Cheng ^1,,

1.
College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 210000, China
2.
Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry & Chemical Engineering, Huaiyin Normal University, Huaian, Anhui 223300, China
3.
College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumchi 830001, China
4.
College of Life Science, Huaiyin Normal University, Huaian, Anhui 223300, China

Corresponding author: ZHONG Hui, huizhong@hytc.edu.cn LI Xiao-Rong, lxr206206@163.com YAO Cheng, yaocheng@njtech.edu.cn
Received Date: 8 July 2020
Revised Date: 12 November 2020

Figures(7)

The folic acid (FA)-grafted magnetic FA-Fe₃O₄/ATP-P(NIPAM-AAM) composite microgels (attapulgite=ATP, N-isopropyl acrylamide=NIPAM, acrylamide=AAM) were prepared via a method of emulsion copolymerization. The as-prepared microgels were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermogravimetric analysis (TG), infrared spectroscopy (IR), UV-visible spectroscopy (UV), scanning electron microscope (SEM) and transmission electron microscope (TEM). The dynamic light scattering (DLS) results show that the low critical solution temperature (LCST) of microgel was about 38.5℃. The drug delivery ability of the as-prepared microgels was evaluated by using doxorubicin hydrochloride (DOX) as the model drug. Based on the drug loading and releasing results, the presence of ATP increased the amount of drug loading and releasing. Compared with free DOX, the in vitro cytotoxicity of DOX loaded FA-Fe₃O₄/ATP-P(NIPAM-AAM) was decreased and the biocompatibility was improved. Those results indicate that the microgels of FA-Fe₃O₄/ATP-P(NIPAM-AAM) can be used in potential as a slow-release drug system. The in vitro cellular uptake test revealed that the microgels of FA-Fe₃O₄/ATP-P(NIPAM-AAM) at the assigned site were significantly richer than that of other sites. This result indicates that the microgels of FA-Fe₃O₄/ATP-P(NIPAM-AAM) composite are targeting and expectable in the application of targeted drug releasing.
- materials chemistry,
- magnetic nanocomposites,
- emulsion polymerization,
- attapulgite,
- temperature-sensitive,
- targeted,
- drug delivery
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