Citation: SUN Bin, WANG Jiang-Lin. Benzothiazole Functionalized Metal Chelators: Synthesis and Bioactivities[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(7): 1275-1282. doi: 10.11862/CJIC.2020.158 shu

Benzothiazole Functionalized Metal Chelators: Synthesis and Bioactivities

SUN Bin ^1,2,, ,
WANG Jiang-Lin ^1,2

1.
Key Laboratory of Natural Medicine Research of Chongqing Education Commission, Chongqing 400067, China
2.
College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, China

Corresponding author: SUN Bin, sunbin@ctbu.edu.cn
Received Date: 25 November 2019
Revised Date: 14 February 2020

Figures(7)

Two benzothiazole modified metal chelators (N, N'-bis (salicylaldehyde)-2, 2'-(3-(benzo[d]-thiozol-2-yl)-1, 2 -phenylene-dioxyethyldiamine (L1), N, N'-bis (salicylaldehyde)-2, 2'-(4-(benzo[d]thiozol-2-yl)-1, 2-phenylene dioxyethyldiamine (L2) were designed and synthesized. The biological activities of chelators were determined by Turbidity Assay, BCA Protein Assay, HRP/Amplex Red Assay and MTT Assay. The results show that these two chelators could effectively prevent aggregation of Aβ_1~40 induced by metal ion (such as Zn²⁺, Cu²⁺), dramatically reduce the product of H₂O₂ which caused by Cu²⁺-Aβ species, and inhibit Aβ aggregation mediated cytotoxicity on PC12 cells. The same assays were carried out for non-benzothiozole functionalized analogue. The non-specific chelator also has above bioactivities, however, its effect was far less than that of the benzothiozole functionalized varieties.
- synthesis,
- Alzheimer's disease,
- benzothiazole functionalized,
- metal chelator,
- antioxidant
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