Citation: XIE Bo, YAO Hua, LIAO Qi-Hua, DENG Rui-Hong, LIN Sen, YAN Zhao-Hua. Synthesis, Structure and Antitumour Activity of Diorganotin(Ⅳ) Complexes Containing Silicon of Salicylaldehyde Thiosemicarbazone[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(5): 819-826. doi: 10.11862/CJIC.2020.101 shu

Synthesis, Structure and Antitumour Activity of Diorganotin(Ⅳ) Complexes Containing Silicon of Salicylaldehyde Thiosemicarbazone

College of Chemistry, Nanchang University, Nanchang 330031, China

Corresponding author: LIN Sen, senlin@ncu.edu.cn
Received Date: 17 October 2019
Revised Date: 27 December 2019

Figures(2)

Eleven diorganotins containing silicon of salicylaldehyde thiosemicarbazone were synthesized and characterized through ¹H NMR, ¹³C NMR, IR spectra, elemental analysis and X-ray single crystal diffraction tests. The result shows that the thiosemicarbazone Schiff base coordinates with tin atom as tridentate dianionic ligand through thephenolic oxygen, imine nitrogen and mercaptan sulfur, forming a parallel five and six-member heterocyclic structures. The preliminary bioassay result shows that these compounds have a good antitumor activity in vitro against MDA-MB-231 and MCF-7.
- diorganotin,
- thiosemicarbazone,
- Schiff base,
- synthesis,
- structure,
- biological activity
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