Citation: GE Chao, Lü Meng-Di, ZHANG Zi-You, CHEN Jun, WANG Meng-Meng, XUE Xu-Ling, QIAN Yong, LIU Hong-Ke. Trends of Platinum and Metal-Arene Anticancer Drugs Based on Natural Products[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(4): 597-606. doi: 10.11862/CJIC.2020.086 shu

Trends of Platinum and Metal-Arene Anticancer Drugs Based on Natural Products

School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

Corresponding author: XUE Xu-Ling, xuexuling87@163.com QIAN Yong, yongqian@njnu.edu.cn
Received Date: 3 September 2019
Revised Date: 10 January 2020

Figures(15)

More than 50% of modern drugs used clinically come from natural products, which can prevent tumor growth and progression by influencing multiple biological pathways such as blocking cell cycle progression, inhibiting cancer cell survival signaling pathway and regulating immune cells. They also show low toxicity to normal tissues. Metal antitumor drugs represented by cisplatin have been widely used in clinical practice. However, they also have severe drug resistance and side effects, such as nephrotoxicity and neurotoxicity. Therefore, modified platinum drugs with natural products are beneficial for overcoming their deficiencies. On the other hand, the emergence of arene-metal complexes provides more possibilities for the development of high-efficiency and low-toxicity anticancer drugs due to their good water solubility and low toxicity towards normal organisms. Combining the respective advantages of natural products and metals opened up new opportunities for the development of anti-cancer drugs, and the development of metal complexes based on natural products as anticancer agents has become a research hotspot. In this paper, the research and mechanism of platinum and arene-metal complexes based on natural products are reviewed comprehensively, and the future development in this field has prospected.
- platinum,
- arene-metal complexes,
- natural products,
- anticancer drugs
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