Citation: LIU Jiao, LI Zhuo-Qun, YI Yu-Yang, ZHONG Yi-Xin, YU Hao-Tian, TAN Yu-Xing, JIANG Wu-Jiu. Syntheses, Crystal Structures and in Vitro Anticancer Activity of Four Binuclear Benzyltin Complexes Based on Acylhydrazone Ligand[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(12): 2200-2208. doi: 10.11862/CJIC.2019.269 shu

Syntheses, Crystal Structures and in Vitro Anticancer Activity of Four Binuclear Benzyltin Complexes Based on Acylhydrazone Ligand

Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: JIANG Wu-Jiu, jwj_china@163.com
Received Date: 27 June 2019
Revised Date: 7 October 2019

Figures(3)

Four dinuclear benzyltin complexes were synthesized by microwave "one-pot synthesis", namely {[C₄H₃S(O)C=N-N=C(Me)COO](PhCH₂)₂Sn(MeOH)}₂ (C1), {[C₄H₃S(O)C=N-N=C(Me)COO](p-Cl-C₆H₄CH₂)₂Sn(MeOH)}₂ (C2), {[C₄H₃S(O)C=N-N=C(PhCH2)COO](PhCH₂)₂Sn(MeOH)}₂ (C3), {[C₄H₃S(O)C=N-N=C(PhCH₂)COO](p-Cl-C₆H₄CH₂)₂Sn(MeOH)}₂ (C4). The complexes C1~C4 were characterized by IR, ¹H NMR, ¹³C NMR¹¹⁹Sn NMR spectra, elemental analysis, HRMS and the crystal structures were determined by X-ray diffraction. The four complexes are all binuclear molecules, and there was a Sn₂O₂ four-membered ring in the middle of the molecule. The central tin atom and the coordinating atom form a seven-coordinated pentagonal bipyramid configuration. The thermogravimetric of the complexes C1~C4 were analyzed, and in vitro antitumor activities of the complexes were evaluated by MTT against three human cancer cell lines (H460, HepG2, MCF7). The results show that complex C2 is the best compound for inhibiting cancer cells in the four synthesized complexes.
- organotin complex,
- acylhydrazone,
- synthesis,
- crystal structure,
- activity
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