Citation: ZHANG Si-Qi, GAO Li-Hua, ZHAO Hua, WANG Ke-Zhi. pH-Sensitive Iridium, Ruthenium and Platinum Complexes for Tumor-Specific Fluorescence Imaging and Cancer Therapy[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(11): 1974-1986. doi: 10.11862/CJIC.2019.231 shu

pH-Sensitive Iridium, Ruthenium and Platinum Complexes for Tumor-Specific Fluorescence Imaging and Cancer Therapy

1.
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
2.
School of Science, Beijing Technology and Business University, Beijing 100048, China

Corresponding author: WANG Ke-Zhi, kzwang@bnu.edu.cn
Received Date: 3 September 2019
Revised Date: 24 September 2019

Figures(8)

Acidic pH in tumor tissues provides a powerful platform for accurate tumor diagnosis and efficient therapy. The pH-sensitive iridium, ruthenium and platinum metal complexes have attracted increasing attention due to their high physicochemical stability, favorable spectral properties and tumor targetability. In this review, we summarize formation mechanisms of the acidic tumor microenvironment and recent advances on the acidic microenvironment-sensitive metal complexes of iridium, ruthenium and platinum for tumor imaging chemotherapy agents.
- metal complex,
- pH sensitive,
- tumor imaging,
- tumor therapy
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