Citation: LI Ze-Ran, ZHU Jian-Ping, YU Han-Yang, CHEN Yun-Cong, HE Wei-Jiang, GUO Zi-Jian. Construction and Fe²⁺ Sensing of a Chelation Based Fe²⁺ Probe[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(11): 2031-2037. doi: 10.11862/CJIC.2019.223 shu

Construction and Fe²⁺ Sensing of a Chelation Based Fe²⁺ Probe

1.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
2.
College of Engineering and Applied Sciences, Nanjing University, Nanjing 210008, China

Corresponding author: CHEN Yun-Cong, chenyc@nju.edu.cn GUO Zi-Jian, zguo@nju.edu.cn
Received Date: 23 May 2019
Revised Date: 24 June 2019

Figures(10)

Iron is the most abundant essential transition metal in human body, and iron disorder has been reported to be associated with many diseases. Therefore, the development of fluorescent probes for Fe²⁺/Fe³⁺ imaging and offering spatial-temporal information of Fe²⁺/Fe³⁺ is of great significance. We chose BODIPY with good stability and high quantum yield as the fluorophore, and the terpyridine with high binding ability to Fe²⁺ as a chelating group. The probe BTPY for Fe²⁺ was constructed by integrating BODIPY with terpyridine at α-position by a vinyl group to form a large conjugated system. The NIR emission at 678 nm and the visible excitation at 582 nm suggest that this probe has the potential for in vivo imaging in animal model. BTPY was able to selectively bind Fe²⁺/Fe³⁺ with a bathochromic absorption shift from 573 to 607 nm and the solution color changed from red to pale blue. In addition, Fe²⁺ caused BTPY fluorescence quenching while Fe³⁺ did not significantly affect the fluorescence. Combining with the spectra change of absorption and emission, this probe can be used for visual detection of iron ions and is able to distinguish Fe²⁺ from Fe³⁺.
- iron ions,
- chelating probe,
- visual detection
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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通讯作者: 陈斌, bchen63@163.com

Construction and Fe²⁺ Sensing of a Chelation Based Fe²⁺ Probe