Citation: YAN Xiao-Lin, GUO Hai-Fu, YAN Peng, ZHU Jia-Min, WANG Ying, TAN Jia-Mei, DING Min, ZHENG Yong-Rui. Synthesis, Characterization and Drug Delivery of a Water-Stable and Methyl-Functionalized 2D Zinc(Ⅱ) Metal-Organic Framework[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(7): 1267-1274. doi: 10.11862/CJIC.2019.137 shu

Synthesis, Characterization and Drug Delivery of a Water-Stable and Methyl-Functionalized 2D Zinc(Ⅱ) Metal-Organic Framework

1.
College of Science, Inner Mongolia Agricultural University, Huhhot 010018, China
2.
School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing, Guangdong 526061, China

Corresponding author: GUO Hai-Fu, guohaifu@sina.com
Received Date: 18 December 2018
Revised Date: 3 April 2019

Figures(6)

By using a methyl-functionalized N-donor ligand, a water-stable zinc-based MOF {[Zn(BDC)(dmbpy)]·4H₂O}_n (1) (BDC=isophthalate, dmbpy=3, 3'-dimethyl-4, 4'-bipyridine) was synthesized and structurally character-ized. TGA and PXRD results show high thermal and water stability for 1.1 exhibits a 2D (4, 4) net with channels of 0.92 nm×0.83 nm and 0.82 nm×0.39 nm along the b axis, respectively. De-solvated 1 adsorbs around 14.2%(w/w) 5-fluorouracil (5-FU) and the cumulative release value of 5-FU after 70 h was about 94.5% and 99% in PBS (pH=7.4 and pH=6.0) at 37℃, respectively. The in vivo zebrafish toxicity tests and in vitro MTT assays of 1 at different concentrations results reveal that 1 is nontoxic (cell viability>80%) up to concentrations of 500 μg·mL^-1.
- zinc-organic framework,
- water-stable,
- synthesis,
- characterization,
- drug delivery
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沈阳化工大学材料科学与工程学院沈阳 110142