Citation: ZHANG Fu-Xing, HE Tang-Feng, YAO Shu-Fen, ZHU Xiao-Ming, SHENG Liang-Bing, KUANG Dai-Zhi, FENG Yong-Lan, YU Jiang-Xi, JIANG Wu-Jiu. Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(4): 598-604. doi: 10.11862/CJIC.2019.083 shu

Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate

Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China

Corresponding author: ZHANG Fu-Xing, zfx8056@163.com
Received Date: 20 August 2018
Revised Date: 30 January 2019

Figures(5)

Di(p-chlorobenzy)tin 2-hydroxybenzoate with ladder-like framework[(μ₃-O)(μ₂-OH)(p-Cl-C₆H₄CH₂Sn)₂(O₂CC₆H₄-OH-o)]₂ (1) and triphenyltin 4-hydroxybenzoate (2) have been synthesized. The complexes were chara-cterized by elemental analysis, IR spectroscopy, thermogravimetric analysis and single-crystal X-ray diffraction. Quantum chemical ab initio calculation as well as in vitro anticancer activity test have been carried out for the complexes. The results showed that complex 1 forms a structure containing Sn₂O₂ ladder-like skeleton and the complex 2 forms a nuclear tin structure. The tin atoms in the complexes all are five-coordinated with distorted trigonal bipyramid geometry. The antitumor activity showed that complexes 1 and 2 have higher activities than cisplatin to HT-29, HepG2, MCF-7, Hela and A549 cell line in vitro. Their thermal stabilities were further investigated, and the results showed that complexes 1 and 2 were stable below 90℃ and below 120℃, respectively.
- organotin hydroxybenzoates,
- crystal structure,
- quantum chemistry,
- in vitro antitumor activity
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