Citation: YANG Chen, WANG Guo-Ping. Syntheses, Crystal Structures and Antitumor Activity of Ni(Ⅱ)/Zn(Ⅱ) Complexes Containing Cephalexin Hydrolysate[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(12): 2172-2178. doi: 10.11862/CJIC.2018.278 shu

Syntheses, Crystal Structures and Antitumor Activity of Ni(Ⅱ)/Zn(Ⅱ) Complexes Containing Cephalexin Hydrolysate

YANG Chen ,
WANG Guo-Ping ^,

Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Corresponding author: WANG Guo-Ping, chewanggp@zju.edu.cn
Received Date: 31 May 2018
Revised Date: 12 October 2018

Figures(7)

Two new mononuclear complexes, [Ni(cepha)₂]·6H₂O (1) and[Zn(cepha)₂]·6H₂O (2) (cepha=cephalo-sporoate) have been synthesized and characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis and X-ray powder diffraction analysis. The structures of complexes have also been determined by X-ray single crystal diffraction analysis, and the results show that the complexes 1 and 2 are both in orthorhombic system with space group P22₁2₁. The cephalexin hydrolyzes during the coordination process to produce cephalosporin intermediate, cephalosporoate (cepha), which participates in coordination. Metal ion acts as six-coordinated center forming a distorted octahedral geometry, and the complexes are further extended to a three-dimensional network via intermolecular hydrogen bonds. The antitumor activity in vitro of cephalexin, metal acetate and complexes were carried out by MTT assay. The results reveal that complexes 1 and 2 have a certain inhibiting activity against MCF-7 and HepG-2 cell lines.
- cephalexin,
- Ni (Ⅱ) complex,
- Zn (Ⅱ) complex,
- crystal structure,
- hydrolysis,
- antitumor activity
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