Citation: CHAI Jie, YANG Bin-Sheng, LIU Bin. Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(10): 1783-1791. doi: 10.11862/CJIC.2018.217 shu

Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives

Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006, China

Corresponding author: YANG Bin-Sheng, yangbs@sxu.edu.cn LIU Bin, liubin@sxu.edu.cn
Received Date: 7 April 2018
Revised Date: 21 June 2018

Figures(8)

Four new chromium picolinate derivatives were synthesized and characterized by X-ray crystal diffraction, ESI-MS, analytical element, conductivity and IR analysis. The effect of substituent groups on its redox property and hydroxyl radical (·OH) generation induced by the complex were investigated by cyclic voltammetry and Fenton-like reaction. As a result, three complexes generate less ·OH than Cr(pic)₃. Besides, acute toxicity and antihyperglycemic effect indicated that high dose of complex 3 is hypotoxic and exhibited more efficiency than Cr(pic)₃ in reducing fasten blood glucose (FBG) and low density lipoprotein by low dose.
- chromium picolinate,
- redox property,
- safety,
- antihyperglycemic effects
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