Citation: ZHAO Ya-Chen, LI Ji, HU Jiong-Sheng, LIU Lu, WANG Meng-Meng, SU Zhi, QIAN Yong, Peter J. Sadler, LIU Hong-Ke. Synthesis, Crystal Structure and DNA Interaction of Mononuclear Osmium Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(10): 1833-1840. doi: 10.11862/CJIC.2018.214 shu

Synthesis, Crystal Structure and DNA Interaction of Mononuclear Osmium Complexes

ZHAO Ya-Chen ¹ ,
LI Ji ¹ ,
HU Jiong-Sheng ¹ ,
LIU Lu ¹ ,
WANG Meng-Meng ¹ ,
SU Zhi ¹ ,
QIAN Yong ^1,, ,
Peter J. Sadler ² ,
LIU Hong-Ke ^1,,

1.
School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
2.
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

Corresponding author: QIAN Yong, liuhongke@njnu.edu.cn LIU Hong-Ke, yongqian@njnu.edu.cn
Received Date: 25 May 2018
Revised Date: 21 June 2018

Figures(7)

Solvothermal reactions of a p-bitmb ligand (4-bis(1-imidazol-1-ylmethyl)-2, 3, 5, 6-tetramethyl benzene) with[Os(arene)Cl₂]₂ in dichloromethane were used to yield novel mononuclear osmium complexes 1 and 2 (1, arene=p-cym; 2, arene=bip), which were fully characterized by ¹H NMR, ESI-MS, elemental analysis and single-crystal X-ray diffraction analysis. X-ray diffraction revealed that 1 is a mononuclear arene-osmium complex, forming a "bowl-like" structure that belongs to monoclinic system with space P2₁/c. The center osmium atom is coordinated with two nitrogen atom from ligands (p-bitmb) and Cl anion, whereas other imidazole ring of ligand is connected by a-CH₂-group to form a dipositive bis-imidazolium center. Cl^- anion can be trapped inside the cavity of this "bowl-like" structure, forming H-bonds with the backbone. ¹H NMR study showed that the source of the bridging-CH₂-group is the solvent, CH₂Cl₂. These complexes are stable in the buffer solution confirmed by the stability study with UV-Vis spectra. Furthermore, the results of UV-Vis spectra, circular dichroism and viscosity measurements revealed significant interactions between 1, 2 and calf thymus DNA (CT-DNA) via the intercalation, reduction of the base stacking, and induction of the DNA despiralization.
- osmium-arene complex,
- crystal structure,
- interaction with DNA
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沈阳化工大学材料科学与工程学院沈阳 110142