Citation: WANG Yan-Hua, HAO Hang, WU Jian-Xiong, YAO Yuan, QIN Na, HE Wen-Cong. Enhanced Antitumor Effect and Drug Delivery from Se Doped Hydroxyapatite Microspheres[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(8): 1517-1530. doi: 10.11862/CJIC.2018.199 shu

Enhanced Antitumor Effect and Drug Delivery from Se Doped Hydroxyapatite Microspheres

WANG Yan-Hua ^1,, ,
HAO Hang ² ,
WU Jian-Xiong ¹ ,
YAO Yuan ¹ ,
QIN Na ¹ ,
HE Wen-Cong ³

1.
Medical College of China Three Gorges University, Yichang, Hubei 443002, China
2.
Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China
3.
The First College of Clinical Medical Science, China Three Gorges University, Yichang 443002, China

Corresponding author: WANG Yan-Hua, wangyanhua@ctgu.edu.cn
Received Date: 11 February 2018
Revised Date: 7 June 2018

Figures(8)

Selenium doped hydroxyapatite microspheres (HASe) were prepared by using self-sacrificing CaCO₃ as template via hydrothermal route, and their physicochemical properties were characterized by SEM, TEM, DLS, XRD, FTIR and TGA. The curcumin was employed as the model drug, and its delivery behavior from HASe microspheres was evaluated with the loading efficacy and controlled-release efficiency. As a result, it was observed that the synthetic HASe products are spherical with an average diameter of about 1.0 μm. The surface of the microspheres is constructed by subtle units of hydroxyapatite nanorods which are 150 nm in length and 20 nm in width. HASe microspheres exhibit a high drug loading efficacy and slowly sustainable release behavior for curcumin. The loading amount of HASe10 was (88.72±0.01) mg·g^-1, and less than 1.5 mg of curcumin was released from it during 0~159 h. There is no burst release but slow sustainable release manner in it. Moreover, the toxicity of HASe microspheres was investigated by blood assay and cell experiment. Compared with selenium-free HA microspheres, HASe microspheres show lower blood toxicity to healthy man, and less damage to normal cells, but stronger inhibition on the growth of the osteosarcoma cells.
- hydroxyapatite,
- selenium,
- hollow microspheres,
- drug delivery system,
- curcumin
1. [1]
  Maia A L, Cavalcante C H, Souza M G, et al. Nucl. Med. Commun., 2016, 37:775-782 doi: 10.1097/MNM.0000000000000510
2. [2]
  ZU Qing-Xia, LI Ya-Ming, HAN Dan. Journal of Functional Materials, 2018, 49(2):2130-2135
3. [3]
  Raina D B, Isaksson H, Hettwer W, et al. Sci. Rep., 2016, 6:26033-26045 doi: 10.1038/srep26033
4. [4]
  Hayashi M, Aoshi T, Kogai Y, et al. Vaccine, 2016, 34:306-312 doi: 10.1016/j.vaccine.2015.11.059
5. [5]
  Wang X P, Li X, Ito A, et al. Chem. Commun., 2016, 52:7078-7081 doi: 10.1039/C6CC02848A
6. [6]
  Bertran O, Revilla-Lopez G, Casanovas J, et al. Chemistry, 2016, 22:6631-6636 doi: 10.1002/chem.201600703
7. [7]
  Ilie A, Ghitulica C, Andronescu E, et al. Int. J. Pharm., 2016, 510:501-507 doi: 10.1016/j.ijpharm.2016.01.025
8. [8]
  Jafari S, Maleki-Dizaji N, Barar J, et al. Eur. J. Pharm. Sci., 2016, 91:225-235 doi: 10.1016/j.ejps.2016.05.014
9. [9]
  Chen X, Yang B, Qi C, et al. Dalton Trans., 2016, 45:1648-1656 doi: 10.1039/C5DT03357H
10. [10]
  Kamitakahara M, Ohtoshi N, Kawashita M, et al. J. Mater. Sci.:Mater. Med., 2016, 27:93-99 doi: 10.1007/s10856-016-5704-7
11. [11]
  Li D, Huang X, Wu Y, et al. Biomater. Sci., 2016, 4:272-280 doi: 10.1039/C5BM00228A
12. [12]
  Benedetti M, De Castro F, Romano A, et al. J. Inorg. Biochem., 2016, 157:73-79 doi: 10.1016/j.jinorgbio.2016.01.019
13. [13]
  Wang Y, Hao H, Zhang S. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 61:545-552 doi: 10.1016/j.msec.2015.12.060
14. [14]
  Lai W, Chen C, Ren X, et al. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 62:166-172 doi: 10.1016/j.msec.2016.01.055
15. [15]
  Yang P P, Quan Z W, Li C X, et al. Biomaterials, 2008, 29:4341-4347 doi: 10.1016/j.biomaterials.2008.07.042
16. [16]
  Xie G P, Sun J A, Zhong G R, et al. J. Mater. Sci.:Mater. Med., 2010, 21:1875-1880 doi: 10.1007/s10856-010-4038-0
17. [17]
  Yang H, Hao L J, Zhao N R, et al. CrystEngComm, 2013, 15:5760-5763 doi: 10.1039/c3ce40710a
18. [18]
  Wan Y Z, Wu C Q, Zuo G F, et al. Mater. Chem. Phys., 2015, 156:238-246 doi: 10.1016/j.matchemphys.2015.03.011
19. [19]
  Ma J, Wang Y, Zhou L, et al. Mater. Sci. Eng. C:Mater. Biol. Appl., 2013, 33:440-445 doi: 10.1016/j.msec.2012.09.011
20. [20]
  Wang Y H, Hao H, Liu H M, et al. Adv. Healthcare Mater., 2015, 4:1813-1818 doi: 10.1002/adhm.v4.12
21. [21]
  Qi C, Zhu Y J, Lu B Q, et al. Chem. Eur. J., 2013, 19:5332-5341 doi: 10.1002/chem.201203886
22. [22]
  Wang Q, Huang W H, Wang D P, et al. J. Mater. Sci.:Mater. Med., 2006, 17:641-646 doi: 10.1007/s10856-006-9227-5
23. [23]
  Yu Y D, Zhu Y J, Qi C, et al. J. Colloid Interface Sci., 2017, 496:416-424 doi: 10.1016/j.jcis.2017.02.041
24. [24]
  Fu H L, Rahaman M N, Day D E, et al. J. Mater. Sci.:Mater. Med., 2011, 22:579-591
25. [25]
  Feng D S, Shi J, Wang X J, et al. RSC Adv., 2013, 3:24975-24982 doi: 10.1039/c3ra44609c
26. [26]
  Zhong Q, Li W, Su X, et al. Colloids Surf. B, 2016, 143:56-63 doi: 10.1016/j.colsurfb.2016.03.020
27. [27]
  Xiao W, Bal B S, Rahaman M N. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 60:324-332 doi: 10.1016/j.msec.2015.11.039
28. [28]
  Xiao Q, Zhou K, Chen C, et al. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 69:1068-1074 doi: 10.1016/j.msec.2016.07.082
29. [29]
  Ma M Y, Zhu Y J, Li L, et al. J. Mater. Chem., 2008, 18:2722-2727 doi: 10.1039/b800389k
30. [30]
  Ye F, Guo H F, Zhang H J, et al. Acta Biomater., 2010, 6:2212-2218 doi: 10.1016/j.actbio.2009.12.014
31. [31]
  Qi C, Zhu Y J, Lu B Q, et al. J. Mater. Chem., 2012, 22:22642-22650 doi: 10.1039/c2jm35280j
32. [32]
  Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, et al. Molecules, 2016, 21:264-285 doi: 10.3390/molecules21030264
33. [33]
  Sarika P R, Nirmala R J. Mater. Sci. Eng. C:Mater. Biol. Appl., 2016, 65:331-337 doi: 10.1016/j.msec.2016.04.044
34. [34]
  Chen P, Wang H, Yang F, et al. J. Cell Biochem., 2017, 118:74-81 doi: 10.1002/jcb.v118.1
35. [35]
  Sahebkar A. Integr. Cancer Ther., 2016, 15:333-334 doi: 10.1177/1534735415624139
36. [36]
  Shi J, Qi W, Du C, et al. J. Appl. Polym. Sci., 2013, 129:577-584 doi: 10.1002/app.38718
37. [37]
  Pizzoccaro M A, Nikel O, Sene S, et al. Acta Biomater., 2016, 41:342-350 doi: 10.1016/j.actbio.2016.06.008
38. [38]
  DAI Zhao, WANG Da-Lin. Chinese Journal of Tissue Engineering Research, 2018, 22(6):938-944 doi: 10.3969/j.issn.2095-4344.0072
1. [1]
  Mochou GAO , Shan MENG , Jinzhong ZHANG , Wenhua FENG , Shuo DONG , Jianping CHEN , Yanbao ZHAO , Laigui YU , Rongrong YING , Xueyan ZOU . Dual‐surface capped hydroxyapatite nano‐amendment with tuned alternate long‐short chain configuration for efficient adsorption towards multi‐heavy metal ions in complex‐contaminated systems. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1427-1438. doi: 10.11862/CJIC.20240431
2. [2]
  Rui Li , Ruijie Lu , Libin Yang , Jianwen Li , Zige Guo , Qiquan Yan , Mengjun Li , Yazhuo Ni , Keying Chen , Yaoyang Li , Bo Xu , Mengzhen Cui , Zhan Li , Zhiying Zhao . Immobilization of chitosan nano-hydroxyapatite alendronate composite microspheres on polyetheretherketone surface to enhance osseointegration by inhibiting osteoclastogenesis and promoting osteogenesis. Chinese Chemical Letters, 2025, 36(4): 110242-. doi: 10.1016/j.cclet.2024.110242
3. [3]
  Kun JIANG , Yutong XUE , Kelin LIU , Miao WANG , Tongming SUN , Yanfeng TANG . CeVO₄ hollow microspheres: Fabrication and adsorption performance for dyes. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2229-2236. doi: 10.11862/CJIC.20250223
4. [4]
  Haijiao Li , Mingzu Zhang , Jinlin He , Jian Liu , Xingwei Sun , Peihong Ni . Synthesis of curcumin polyprodrug via click chemistry and construction of dual-drug-loaded nano platform for highly efficient tumor treatment. Chinese Chemical Letters, 2025, 36(8): 110615-. doi: 10.1016/j.cclet.2024.110615
5. [5]
  Jiajie Gu , Jiaxiang Gu , Lei Yu . Selenium and Alzheimer's disease. Chinese Chemical Letters, 2025, 36(8): 110727-. doi: 10.1016/j.cclet.2024.110727
6. [6]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
7. [7]
  Ying Xu , Chengying Shen , Hailong Yuan , Wei Wu . Mapping multiple phases in curcumin binary solid dispersions by fluorescence contrasting. Chinese Chemical Letters, 2024, 35(9): 109324-. doi: 10.1016/j.cclet.2023.109324
8. [8]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
9. [9]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
10. [10]
  Fengzhang TU , Zhong JIN . Honeycomb-like N, O dual-doped carbon/selenium composites: Preparation and performance in alkali metal-selenium batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2371-2384. doi: 10.11862/CJIC.20250227
11. [11]
  Qi Huang , Jun Liao , Jingjing Li , Zhengyan Gu , Xinkang Zhang , Mingxue Sun , Wenqi Meng , Guanchao Mao , Zhipeng Pei , Shanshan Zhang , Songling Li , Chuan Zhang , Yunqin Wang , Jihao Liu , Tingbin Shu , Min Tao , Ying Lu , Kai Xiao , Qingqiang Xu , Jincai Lu . Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury. Chinese Chemical Letters, 2025, 36(4): 109914-. doi: 10.1016/j.cclet.2024.109914
12. [12]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
13. [13]
  Jing Feng , Yanhong Liu , Liming Gong , Chenfei Liu , Congcong Xiao , Liqing Chen , Mingji Jin , Zhonggao Gao , Wei Huang , Yubo Li . Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy. Chinese Chemical Letters, 2025, 36(11): 110907-. doi: 10.1016/j.cclet.2025.110907
14. [14]
  Jiahui Li , Qiao Shi , Ying Xue , Mingde Zheng , Long Liu , Tuoyu Geng , Daoqing Gong , Minmeng Zhao . The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers. Chinese Chemical Letters, 2024, 35(6): 109239-. doi: 10.1016/j.cclet.2023.109239
15. [15]
  Zhi Li , Shuya Pan , Yuan Tian , Shaowei Liu , Weifeng Wei , Jinlin Wang , Tianfeng Chen , Ling Wang . Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer. Chinese Chemical Letters, 2024, 35(12): 110018-. doi: 10.1016/j.cclet.2024.110018
16. [16]
  Lu Huang , Jiang Wang , Hong Jiang , Lanfang Chen , Huanwen Chen . On-line determination of selenium compounds in tea infusion by extractive electrospray ionization mass spectrometry combined with a heating reaction device. Chinese Chemical Letters, 2025, 36(1): 109896-. doi: 10.1016/j.cclet.2024.109896
17. [17]
  Zhi-Peng Zhou , Xin Wei , Ming Yan , Zhi-Guo Wang , Rui Hong , Jia-Zhuang Xu . Multifunctional selenium nanoparticles/gelatin-based nanocomposite hydrogel adhesive for accelerated full-thickness wound healing. Chinese Chemical Letters, 2025, 36(9): 111400-. doi: 10.1016/j.cclet.2025.111400
18. [18]
  Wenxue Wang , Longwei Bai , Na Li , Shuo Zhao , Xiaodong Shi , Peng Wang . Selenium-doping metal phosphides as bifunctional catalyst carrier for durable lithium-sulfur batteries. Chinese Chemical Letters, 2025, 36(10): 110938-. doi: 10.1016/j.cclet.2025.110938
19. [19]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
20. [20]
  Peng Liu . Cyclodextrins as versatile supramolecular building block in nanoscale drug delivery systems for precise tumor chemotherapy. Chinese Chemical Letters, 2025, 36(11): 111406-. doi: 10.1016/j.cclet.2025.111406

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(2126)
HTML views(98)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142