Citation: GE Chao, WANG Hong-Yan, DONG Yi-Li, LI Ji, XU Yun, GU Qiu-Yu, SU Zhi, QIAN Yong, Peter J. Sadler, LIU Hong-Ke. Ru(Ⅱ)-Arene Complexes Based on Bipyridyl Derivatives Ligand: Syntheses, Characterization and Interaction with DNA/BSA[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(6): 1079-1085. doi: 10.11862/CJIC.2018.148 shu

Ru(Ⅱ)-Arene Complexes Based on Bipyridyl Derivatives Ligand: Syntheses, Characterization and Interaction with DNA/BSA

GE Chao ¹ ,
WANG Hong-Yan ¹ ,
DONG Yi-Li ¹ ,
LI Ji ¹ ,
XU Yun ¹ ,
GU Qiu-Yu ¹ ,
SU Zhi ¹ ,
QIAN Yong ^1,, ,
Peter J. Sadler ² ,
LIU Hong-Ke ^1,,

1.
School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
2.
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK

Corresponding author: QIAN Yong, 07250@njnu.edu.cn LIU Hong-Ke, liuhongke@njnu.edu.cn
Received Date: 6 November 2017
Revised Date: 23 April 2018

Figures(5)

Two novel ruthenium-arene complexes of general formula[Ru(η⁶-p-cymene)(L)Cl]Cl, where L=4, 4'-dimethyl-2, 2'-bipyridine (1), 4'-methyl-(2, 2'-bipyridine)-4-carbaldehyde oxime (2), were synthesized. They were characterized by elemental analysis, mass spectrometry and ¹H NMR spectroscopy. The hydrolytic property and binding activity of complexes with CT-DNA and serum proteins were detected by UV spectroscopy and fluorescence spectroscopy; the cytotoxic assay was also conducted. The results indicated that 1 is more dynamically stable in the aqueous solution than 2. Complexes 1 and 2 bind to DNA double helix structure via intercalation with the binding constants of 7.8×10³ L·mol^-1 (1) and 1.86×10⁴ L·mol^-1 (2), respectively. These complexes also exhibit strong interaction with protein and cause quiescent quenching of proteins with the binding constants of 1.04×10⁵ L·mol^-1 (1) and 8.62×10⁴ L·mol^-1 (2), respectively. Strong binding ability between complexes and protein may be the reason of low cytotoxicity.
- ruthenium-arene,
- bipyridine,
- DNA/BSA binding
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