Citation: LI Yun-Tong, DONG Jing-Wen, LU Yao, GU Yi-Tong, SHANG Chao-Nan, LIU Fu-Yao, XIN Yu, JING Chang-Ling, YOU Zhong-Lu. Syntheses, Crystal Structures and Urease Inhibition of Two Manganese(Ⅲ) Complexes with Bis-Schiff Bases[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(6): 1192-1198. doi: 10.11862/CJIC.2018.147 shu

Syntheses, Crystal Structures and Urease Inhibition of Two Manganese(Ⅲ) Complexes with Bis-Schiff Bases

1.
Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China
2.
Liaoxi Yuming High School, Jinzhou, Liaoning 121000, China

Corresponding author: YOU Zhong-Lu, youzhonglu@126.com
Received Date: 20 January 2018
Revised Date: 15 March 2018

Figures(6)

A bis-Schiff base N, N'-bis(3, 5-difluorosalicylidene)-1, 3-diaminopropane) (H₂L) was prepared. Reaction of H₂L and manganese acetate with ammonium thiocyanate or sodium azide in methanol gave complexes[MnL(NCS)(OH₂)] (1) and[MnL(μ_{1, 3}-N₃)]_n (2), respectively. H₂L and the complexes were characterized by elemental analysis, IR spectra, ¹H NMR spectra, and the crystal structures of the complexes were analyzed by single crystal X-ray diffraction. The Schiff base ligand coordinates to the Mn atom through the imino nitrogen and phenolate oxygen. The thiocyanate ligand coordinates to the Mn atom through the nitrogen atom, and the azide ligand coordinates to the Mn atom, with a bridging mode, through two terminal nitrogen atoms. In both complexes, the Mn atoms adopt octahedral coordination. The Schiff base and the complexes were tested for their Jack bean urease inhibitory activities. For complex 1, the inhibition rate at concentration of 100 μmol·L^-1 on the urease is (52.0±3.1)%, and the IC₅₀ value is (81.0±3.7) μmol·L^-1. While for complex 2, it has no activity against the urease. Molecular docking study of complex 1 was performed to study the inhibition.
- Schiff base,
- manganese(Ⅲ)complex,
- crystal structure,
- urease inhibitor
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沈阳化工大学材料科学与工程学院沈阳 110142