Citation: KUANG Dai-Zhi, YU Jiang-Xi, FENG Yong-Lan, ZHU Xiao-Ming, JIANG Wu-Jiu, ZHANG Fu-Xing. Syntheses, Structures and in Vitro Antitumor Activity of Bis(tricyclohexyltin) Pyridinedicarboxylate with Macrocyclic Supramolecular Structure[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(6): 1035-1042. doi: 10.11862/CJIC.2018.111 shu

Syntheses, Structures and in Vitro Antitumor Activity of Bis(tricyclohexyltin) Pyridinedicarboxylate with Macrocyclic Supramolecular Structure

Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: KUANG Dai-Zhi, hnkcq@qq.com
Received Date: 7 December 2017
Revised Date: 6 March 2018

Figures(3)

Four bis(tricyclohexyltin)pyridinedicarboxylates, {[(2, 6-Hpydc)SnCy₃]·MeOH}_n (1), [(2, 6-pydc)Sn₂Cy₆(H₂O)]·PhH (2), [(3, 5-pydc)Sn₂Cy₆(MeOH)]·MeOH (3) and[(3, 5-pydc)Sn₂Cy₆(H₂O)]·EtOH (4), have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide with 2, 6-H₂pydc and 3, 5-H₂pydc (H₂pydc=pyridinedicarboxylic acid), respectively. Compounds 1~4 have been characterized by elemental, IR, (¹H, ¹³C and ¹¹⁹Sn) NMR and single crystal X-ray diffraction analyses. The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and ligand atoms. These compounds has a 2D network with macrocyclic supramolecular by the hydrogen bonding interaction of the neighboring molecule. The antitumor activity showed that compounds 1 and 3 have higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro.
- tricyclohexyltinpyridinedicarboxylate,
- microwave solvothermal synthesis,
- structure,
- in vitro antitumor activity
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