Citation: MA Xiao-Yu, LIU Yong-Jia, ZHU Bang-Shang. Preparation and Drug Delivery Properties of Mg-Doped Hydroxyapatite Nanoparticles[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(5): 917-924. doi: 10.11862/CJIC.2018.106 shu

Preparation and Drug Delivery Properties of Mg-Doped Hydroxyapatite Nanoparticles

1.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
2.
Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China

Corresponding author: ZHU Bang-Shang, bshzhu@sjtu.edu.cn
Received Date: 24 November 2017
Revised Date: 26 January 2018

Figures(9)

Magnesium-doped hydroxyapatites nanoparticles (Mg-HAs) with different feeding molar ratios were synthesized by step precipitation reaction and one pot reaction. The morphology and size of the Mg-HAs were controlled by different feeding molar ratio of magnesium nitrate and calcium nitrate. The Mg-HAs were characterized by transmission electron microscope, X-ray diffraction, et al. MTT method was used to evaluated in vitro cytotoxicity of the Mg-HAs. Results show that the synthesized Mg-HAs had the frame with fiber like structure, high specific surface area and low cell cytotoxicity. Mg-HAs as drug carrier material and cisplatin (cDDP) as a model drug were investigated, and the max loading rate was 54.84%. The drug loading Mg-HAs also have release properties (the releasing rate is 41.72% after 72 h), and a better inhibitory effect on cancer cells.
- magnesium doped hydroxyapatite,
- step reaction,
- cisplatin,
- drug loading
1. [1]
  Iijima M, Moriwaki Y, Yamaguchi R, et al. Connect. Tissue Res., 1997, 36(2):73-83 doi: 10.3109/03008209709160215
2. [2]
  Vallet-Regí M, González-Calbet J M. Prog. Solid State Chem., 2004, 32(1):1-31
3. [3]
  Wang L, Nancollas G H. Chem. Rev., 2008, 108(11):4628-4669 doi: 10.1021/cr0782574
4. [4]
  Dorozhkin S V. Biomaterials, 2010, 31(7):1465-1485 doi: 10.1016/j.biomaterials.2009.11.050
5. [5]
  Zhao J, Duan K, Zhang J W, et al. Mater. Sci. Eng., C, 2011, 31(3):697-701 doi: 10.1016/j.msec.2010.12.011
6. [6]
  Fathi M H, Hanifi A, Mortazavi V. J. Mater. Process. Technol., 2008, 202(1/2/3):536-542
7. [7]
  Abdulkareem E H, Memarzadeh K, Allaker R P, et al. J. Dent., 2015, 43(12):1462-1469 doi: 10.1016/j.jdent.2015.10.010
8. [8]
  Ye F, Guo H, Zhang H, et al. Acta Biomater., 2010, 6(6):2212-2218 doi: 10.1016/j.actbio.2009.12.014
9. [9]
  Sun R, Chen K, Lu Y. Mater. Res. Bull., 2009, 44(10):1939-1942 doi: 10.1016/j.materresbull.2009.06.015
10. [10]
  Zhao Q F, Wang T Y, Wang J, et al. Appl. Surf. Sci., 2011, 257(23):10126-10133 doi: 10.1016/j.apsusc.2011.06.161
11. [11]
  Gomes S, Nedelec J M, Jallot E, et al. Chem. Mater., 2011, 23(12):3072-3085 doi: 10.1021/cm200537v
12. [12]
  Murata H, Shitara K, Tanaka I, et al. J. Phys.:Condens. Matter, 2010, 22(38):384213-384218 doi: 10.1088/0953-8984/22/38/384213
13. [13]
  Evis Z, Webster T J. Adv. Appl. Ceram., 2011, 110(5):311-320 doi: 10.1179/1743676110Y.0000000005
14. [14]
  Webster T J, Massa-Schlueter E A, Smith J L, et al. Biomaterials, 2004, 25(11):2111-2121 doi: 10.1016/j.biomaterials.2003.09.001
15. [15]
  ZHAO Hong-Xia, JIN Hua, CAI Ji-Ye. Chinese J. Inorg. Chem., 2010, 26(1):106-111
16. [16]
  YAO Ai-Hua, XU Wei, AI Fan Rong, et al. J. Inorg. Mater., 2011, 26(9):974-978
17. [17]
  Niki Y, Matsumoto H, Suda Y, et al. Biomaterials, 2003, 24(8):1447-1457 doi: 10.1016/S0142-9612(02)00531-8
18. [18]
  Kalita S J, Bhatt H A. Mater. Sci. Eng., C, 2007, 27(4):837-848 doi: 10.1016/j.msec.2006.09.036
19. [19]
  Suchanek W L, Byrappa K, Shuk P, et al. Biomaterials, 2004, 25(19):4647-4657 doi: 10.1016/j.biomaterials.2003.12.008
20. [20]
  Kim S R, Lee J H, Kim Y T, et al. Biomaterials, 2003, 24(8):1389-1398 doi: 10.1016/S0142-9612(02)00523-9
21. [21]
  Landi E, Logroscino G, Proietti L, et al. J. Mater. Sci.-Mater. Med., 2008, 19(1):239-247 doi: 10.1007/s10856-006-0032-y
22. [22]
  Bigi A, Falini G, Foresti E, et al. J. Inorg. Biochem., 1993, 49(1):69-78 doi: 10.1016/0162-0134(93)80049-F
23. [23]
  Wan Y Z, Huang Y, He F, et al. Surf. Coat. Technol., 2006, 201(6):2904-2909 doi: 10.1016/j.surfcoat.2006.06.004
24. [24]
  Zhang X J, Lin D Y, Yan X H, et al. J. Cryst. Growth, 2011, 336(1):60-66 doi: 10.1016/j.jcrysgro.2011.09.039
25. [25]
  Ren F, Leng Y, Xin R, et al. Acta Biomater., 2010, 6(7):2787-2796 doi: 10.1016/j.actbio.2009.12.044
26. [26]
  Yuan X Y, Zhu B S, Tong G S, et al. J. Mater. Chem. B, 2013, 1(47):6551-6559 doi: 10.1039/c3tb21315c
27. [27]
  Eslami H, Solati-Hashjin M, Tahriri M. Journal of Ceramic Processing Research, 2008, 9(3):224-229
28. [28]
  Ren F, Leng Y R, Ge X. Acta Biomater., 2010, 6(7):2787-2796 doi: 10.1016/j.actbio.2009.12.044
29. [29]
  Kawasaki T, Niikura M, Kobayashi Y. J. Chromatogr. A, 1990, 515:125-148 doi: 10.1016/S0021-9673(01)89307-9
30. [30]
  Ulbrich K, Etrych T, Chytil P, et al. Adv. Drug Delivery Rev., 2004, 277(1/2):63-72
31. [31]
  Kratz F, Beyer U, Schütte M T. Crit. Rev. Ther. Drug Carrier Syst., 1999, 16(3):245-248 doi: 10.1615/CritRevTherDrugCarrierSyst.v16.i3
32. [32]
  Rodrigues P C, Roth T, Fiebig H, et al. Bioorg. Med. Chem., 2006, 14(12):4110-4117 doi: 10.1016/j.bmc.2006.02.007
1. [1]
  Jingke LIU , Jia CHEN , Yingchao HAN . Nano hydroxyapatite stable suspension system: Preparation and cobalt adsorption performance. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1763-1774. doi: 10.11862/CJIC.20240060
2. [2]
  Yuhao SUN , Qingzhe DONG , Lei ZHAO , Xiaodan JIANG , Hailing GUO , Xianglong MENG , Yongmei GUO . Synthesis and antibacterial properties of silver-loaded sod-based zeolite. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 761-770. doi: 10.11862/CJIC.20230169
3. [3]
  Chunmei GUO , Weihan YIN , Jingyi SHI , Jianhang ZHAO , Ying CHEN , Quli FAN . Facile construction and peroxidase-like activity of single-atom platinum nanozyme. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1633-1639. doi: 10.11862/CJIC.20240162
4. [4]
  Feiya Cao , Qixin Wang , Pu Li , Zhirong Xing , Ziyu Song , Heng Zhang , Zhibin Zhou , Wenfang Feng . Magnesium-Ion Conducting Electrolyte Based on Grignard Reaction: Synthesis and Properties. University Chemistry, 2024, 39(3): 359-368. doi: 10.3866/PKU.DXHX202308094
5. [5]
  Jiangjuan Shao , Xuan Li , Jingdan Weng , Xiaolei Chen , Fei Xu , Yulu Ma , Nianguang Li , Shizhong Zheng . Improvement in the Experimental Teaching Design of Physical and Chemical Identification and Quantification of Mineral Drugs. University Chemistry, 2024, 39(10): 137-142. doi: 10.3866/PKU.DXHX202312079
6. [6]
  Xiaomei Ning , Liang Zhan , Xiaosong Zhou , Jin Luo , Xunfu Zhou , Cuifen Luo . Preparation and Electro-Oxidation Performance of PtBi Supported on Carbon Cloth: A Recommended Comprehensive Chemical Experiment. University Chemistry, 2024, 39(11): 217-224. doi: 10.3866/PKU.DXHX202401085
7. [7]
  Endong YANG , Haoze TIAN , Ke ZHANG , Yongbing LOU . Efficient oxygen evolution reaction of CuCo₂O₄/NiFe-layered bimetallic hydroxide core-shell nanoflower sphere arrays. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 930-940. doi: 10.11862/CJIC.20230369
8. [8]
  Peng ZHOU , Xiao CAI , Qingxiang MA , Xu LIU . Effects of Cu doping on the structure and optical properties of Au₁₁(dppf)₄Cl₂ nanocluster. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1254-1260. doi: 10.11862/CJIC.20240047
9. [9]
  Qingtang ZHANG , Xiaoyu WU , Zheng WANG , Xiaomei WANG . Performance of nano Li₂FeSiO₄/C cathode material co-doped by potassium and chlorine ions. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1689-1696. doi: 10.11862/CJIC.20240115
10. [10]
  Hailang JIA , Hongcheng LI , Pengcheng JI , Yang TENG , Mingyun GUAN . Preparation and performance of N-doped carbon nanotubes composite Co₃O₄ as oxygen reduction reaction electrocatalysts. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 693-700. doi: 10.11862/CJIC.20230402
11. [11]
  Qiangqiang SUN , Pengcheng ZHAO , Ruoyu WU , Baoyue CAO . Multistage microporous bifunctional catalyst constructed by P-doped nickel-based sulfide ultra-thin nanosheets for energy-efficient hydrogen production from water electrolysis. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1151-1161. doi: 10.11862/CJIC.20230454
12. [12]
  Jinyi Sun , Lin Ma , Yanjie Xi , Jing Wang . Preparation and Electrocatalytic Nitrogen Reduction Performance Study of Vanadium Nitride@Nitrogen-Doped Carbon Composite Nanomaterials: A Recommended Comprehensive Chemistry Experiment. University Chemistry, 2024, 39(4): 184-191. doi: 10.3866/PKU.DXHX202310094
13. [13]
  Hui Shi , Shuangyan Huan , Yuzhi Wang . Ideological and Political Design of Potassium Permanganate Oxidation-Reduction Titration Experiment. University Chemistry, 2024, 39(2): 175-180. doi: 10.3866/PKU.DXHX202308042
14. [14]
  Zhenlin Zhou , Siyuan Chen , Yi Liu , Chengguo Hu , Faqiong Zhao . A New Program of Voltammetry Experiment Teaching Based on Laser-Scribed Graphene Electrode. University Chemistry, 2024, 39(2): 358-370. doi: 10.3866/PKU.DXHX202308049
15. [15]
  Feng Liang , Desheng Li , Yuting Jiang , Jiaxin Dong , Dongcheng Liu , Xingcan Shen . Method Exploration and Instrument Innovation for the Experiment of Colloid ζ Potential Measurement by Electrophoresis. University Chemistry, 2024, 39(5): 345-353. doi: 10.3866/PKU.DXHX202312009
16. [16]
  Wei Peng , Baoying Wen , Huamin Li , Yiru Wang , Jianfeng Li . Exploration and Practice on Raman Scattering Spectroscopy Experimental Teaching. University Chemistry, 2024, 39(8): 230-240. doi: 10.3866/PKU.DXHX202312062
17. [17]
  Yujia Luo , Yunpeng Qi , Huiping Xing , Yuhu Li . The Use of Viscosity Method for Predicting the Life Expectancy of Xuan Paper-based Heritage Objects. University Chemistry, 2024, 39(8): 290-294. doi: 10.3866/PKU.DXHX202401037
18. [18]
  Tiejun Su . The Construction and Application of the Calculation Formula for Endpoint Error in Precipitation Titration: A Case Study of the Mohr Method. University Chemistry, 2024, 39(11): 384-387. doi: 10.12461/PKU.DXHX202402039
19. [19]
  Wentao Lin , Wenfeng Wang , Yaofeng Yuan , Chunfa Xu . Concerted Nucleophilic Aromatic Substitution Reactions. University Chemistry, 2024, 39(6): 226-230. doi: 10.3866/PKU.DXHX202310095
20. [20]
  Heng Zhang . Determination of All Rate Constants in the Enzyme Catalyzed Reactions Based on Michaelis-Menten Mechanism. University Chemistry, 2024, 39(4): 395-400. doi: 10.3866/PKU.DXHX202310047

Get Citation

PDF

XML

Metrics

PDF Downloads(8)
Abstract views(1272)
HTML views(394)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142