Citation: XIE Qing-Fan, GUO Miao-Li, CHEN Yan-Min. Binuclear Cobalt(Ⅱ) and Nickel(Ⅱ) Complexes with o-Aminophenol Schiff Base: Syntheses, Structures, Antitumor Activity and Quantum Chemistry Calculation[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(2): 309-316. doi: 10.11862/CJIC.2018.028 shu

Binuclear Cobalt(Ⅱ) and Nickel(Ⅱ) Complexes with o-Aminophenol Schiff Base: Syntheses, Structures, Antitumor Activity and Quantum Chemistry Calculation

College of Chemical Engineering and Material, Quanzhou Normal University, Quanzhou, Fujian 362000, China

Corresponding author: CHEN Yan-Min, qzucym@163.com
Received Date: 17 July 2017
Revised Date: 3 November 2017

Figures(8)

A five-coordinated binuclear cobalt(Ⅱ) complex with the formula[Co₂(H₂O)₂(L1)₂(4, 4'-bipy)] (1) (H₂L1=2-hydroxybenzene (2-hydroxyl-5-nitro-phenyl-methyl) amine) was hydrothermally synthesized and a binuclear nickel(Ⅱ) complex of general formula[Ni₂(L2)₂(4, 4'-bipy)] (2) (H₂L2=2-hydroxybenzene (2-hydroxyl-phenyl-methyl) amine) synthesized by using evaporation method, and the comlexes were characterized by IR, UV-Vis spectra and TGA. The X-ray diffraction analyses reveal that 1 crystallizes in the triclinic space group P1 while 2 in trigonal space group R3. The antitumor activity in vitro of ligands and complexes were measured by MTT method, and the results show that the complexes 1 and 2 possess inhibiting effects to HEPG2 and SW620 cancer cells lines. The quantum chemical calculation for 2 was performed by means of Gaussian 09 program at UB3LYP/6-31G(d) basis set. CCDC: 1440518, 1; 1432468, 2.
- binuclear complex,
- crystal structure,
- antitumor activity,
- quantum chemistry calculation
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