Citation: ZHANG Zhi-Jian, JIANG Wu-Jiu, LIU Yang, KUANG Dai-Zhi, YU Jiang-Xi, ZHU Xiao-Ming, TAN Yu-Xing. Syntheses, Crystal Structures and Biological Activity of N-(2-Propionic acid)-aroyl Hydrazone Di-p-methylbenzytin Complexes[J]. Chinese Journal of Inorganic Chemistry, ;2017, 33(9): 1603-1610. doi: 10.11862/CJIC.2017.198 shu

Syntheses, Crystal Structures and Biological Activity of N-(2-Propionic acid)-aroyl Hydrazone Di-p-methylbenzytin Complexes

Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: TAN Yu-Xing, 358050086@qq.com
Received Date: 4 May 2017
Revised Date: 1 August 2017

Figures(8)

Two substituted benzyltin complexes (C1, C2) has been synthesized via the reaction of N-(2-propionic acid)-aroyl hydrazone with di-p-methylbenzytin dichloride. The complexes C1 and C2 have been characterized by IR, UV-Vis, ¹H NMR, ¹³C NMR ¹¹⁹Sn NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes were evaluated by the 3-(4, 5-dimethylthiazoly-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines(H460, HepG2, MCF7) and a human cell line(HL7702). Two complexes exhibit strong antitumor activity, moreover, C2 is less toxic than C1. The result of EB fluorescent probe shows the interaction between complexes and calf thymus DNA is intercalation. CCDC: 1457502, C1; 1547503, C2.
- organotin complex,
- hydrazone,
- synthesis,
- crystal structure,
- biological activity
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