Citation: GAO An-Li, QIU Jie, HOU Shu-Qian, JIANG Jing, LOU Li-Guang, LIU Wei-Ping. Synthesis and Anticancer Activity of cis-[Pt (Ⅱ)(trans-1, 2-bis (methylamino) cyclobutane) (3-hydroxyl-1, 1-cyclobutanedicarboxylate)][J]. Chinese Journal of Inorganic Chemistry, ;2017, 33(5): 837-842. doi: 10.11862/CJIC.2017.096 shu

Synthesis and Anticancer Activity of cis-[Pt (Ⅱ)(trans-1, 2-bis (methylamino) cyclobutane) (3-hydroxyl-1, 1-cyclobutanedicarboxylate)]

GAO An-Li ¹ ,
QIU Jie ² ,
HOU Shu-Qian ¹ ,
JIANG Jing ^1,*,, ,
LOU Li-Guang ³ ,
LIU Wei-Ping ^1,*,,

1.
Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming 650106, China
2.
Lincang Maternal and Child Health Care Hospital, Lincang, Yunnan 677000, China
3.
Tumor PharmacologyLab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Corresponding author: JIANG Jing, dianaair@126.com LIU Wei-Ping, liuweiping1963@126.com
Received Date: 1 December 2016
Revised Date: 14 March 2017

Figures(4)

A new water-soluble and more water-stable analogue of lobaplatin, cis-[Pt (Ⅱ)(trans-1, 2-bis (methylamino) cyclobutane)(3-hydroxyl-1, 1-cyclobutanedicarboxylate)], was designed, with an attempt to improve the water-stability of lobaplatin while retaining its excellent anticancer profile, via the structural recombination and optimization of lobaplatin and carboplatin. The analogue was synthesized by the direct reaction between cis-[Pt (Ⅱ)(trans-1, 2-bis (methylamino)) I₂] as an intermediate and the silver salt of 3-hydroxyl-1, 1-cyclobutanedicarboxylic acid, and characterized by elemental analysis, ESI-MS, IR and ¹H, ¹³C NMR. The anticancer activity was evaluated by both in vitro cyotoxicity against four human cancer cell lines and in vivo antitumor efficiency in human lung carcinoma NCI-H460 xenografts in nude mice. The biological tests revealed that the analogue produced significant inhibition of the tumor growth, resulting in an inhibitory rate of 54% at the dose of 60 mg·kg^-1 and more importantly, it had in vivo anticancer activity comparable to that of lobaplatin.
- platinum complexes,
- synthesis,
- characterization,
- anticancer activity
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沈阳化工大学材料科学与工程学院沈阳 110142