Citation: LI Ling, LÜ Kai-Wen, LI Yun-Tong, JIANG Gui-Fa, XIN Yu, YE Lei, ZHANG Yan, LIU Hui, SHANG Chao-Nan, YOU Zhong-Lu. Syntheses, Crystal Structures and Insulin-like Activity of Maltolato-and Ethylmaltolato-Coordinated Oxovanadium (Ⅴ) Complexes Derived from 4-Fluoro-N'-(3-ethoxy-2-hydroxybenzylidene) benzohydrazide[J]. Chinese Journal of Inorganic Chemistry, ;2017, 33(5): 905-912. doi: 10.11862/CJIC.2017.094 shu

Syntheses, Crystal Structures and Insulin-like Activity of Maltolato-and Ethylmaltolato-Coordinated Oxovanadium (Ⅴ) Complexes Derived from 4-Fluoro-N'-(3-ethoxy-2-hydroxybenzylidene) benzohydrazide

Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China

Corresponding author: YOU Zhong-Lu, youzhonglu@126.com
Received Date: 20 February 2017
Revised Date: 22 March 2017

Figures(5)

A new aroylhydrazone compound 4-fluoro-N'-(3-ethoxy-2-hydroxybenzylidene) benzohydrazide (H₂L) was prepared. Reaction of H₂L and VO (acac)₂ with maltol (mat) and ethylmaltol (Emat), respectively, in methanol afforded the complexes[VO (L)(mat)] (1) and[VO (L)(Emat)] (2). Both H₂L and the oxovanadium complexes were characterized by elemental analysis, IR, UV-Vis and ¹H NMR spectra. The structures of the compounds were further confirmed by single crystal X-ray diffraction. The aroylhydrazone ligand, in its dianionic form, coordinated to the V atoms through the phenolate oxygen, imino nitrogen and enolate oxygen. The maltol and ethylmaltol ligands coordinated to the V atoms through the carbonyl oxygen and deprotonated hydroxyl oxygen. The V atom in each complex is in octahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mice for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mgV·kg^-1, can significantly decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered.
- aroylhydrazone,
- oxovanadium (Ⅴ) complex,
- crystal structure,
- insulin-like activity
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