Citation: MAO Pan-Dong, HAN Xue-Feng, LI Shan-Shan, SHI Lin-Ying, WANG Yuan, WU Wei-Na. Syntheses, Crystal Structures and DNA-Binding Properties of Ni(Ⅱ)/Zn(Ⅱ)/Cd(Ⅱ)/Cu(Ⅱ) Complexes with 4-Methyl-1-((quinolin-8-yl) methylene)-thiosemicarbazide[J]. Chinese Journal of Inorganic Chemistry, ;2017, 33(4): 692-698. doi: 10.11862/CJIC.2017.067 shu

Syntheses, Crystal Structures and DNA-Binding Properties of Ni(Ⅱ)/Zn(Ⅱ)/Cd(Ⅱ)/Cu(Ⅱ) Complexes with 4-Methyl-1-((quinolin-8-yl) methylene)-thiosemicarbazide

MAO Pan-Dong ¹ ,
HAN Xue-Feng ^2,*,, ,
LI Shan-Shan ¹ ,
SHI Lin-Ying ¹ ,
WANG Yuan ¹ ,
WU Wei-Na ^1,*,,

1.
College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, China
2.
Personnel Division, Henan Polytechnic University, Jiaozuo, Henan 454000, China

Corresponding author: HAN Xue-Feng, 108242720@qq.com WU Wei-Na, wuwn08@hpu.edu.cn
Received Date: 22 November 2016
Revised Date: 18 January 2017

Figures(4)

Four complexes[NiL₂]·2CH₃OH (1), [ZnL₂]·CH₃OH (2), [CdL₂]·CH₃CH₂OH (3) and[Cu₂L₂Cl₂] (4) (HL=4-methyl-1-((quinolin-8-yl) methylene)-thiosemicarbazide) have been synthesized and structurally determined by single-crystal X-ray diffraction. The results show that the structures of complexes 1~3 are quite similar. The metal ion in each complex with a distorted octahedron geometry is surrounded by two anionic thiosemicarbazone ligands with N₄S₂ donor set. However, complex 4 is binuclear, and each central Cu(Ⅱ) ion is coordinated by one independent neutral ligand HL and three chloride anions, two of which act as μ²-bridges. In addition, the fluorescence spectra indicate that the interactions of the complex es with DNA, particularly of the complex 4, are stronger than that of the ligand HL.
- quinoline,
- thiosemicarbazone,
- complex,
- crystal structure,
- DNA interaction
1. [1]
  Majid R, Hassan K. Coord. Chem. Rev., 2014, 280:203-253 doi: 10.1016/j.ccr.2014.06.007
2. [2]
  Soares M A, Lessa J A, Mendes I C, et al. Bioorg. Med. Chem., 2012, 20:3396-3409 doi: 10.1016/j.bmc.2012.04.027
3. [3]
  Qi J, Liang S, Gou Y, et al. Eur. J. Med. Chem., 2015, 96:360-368 doi: 10.1016/j.ejmech.2015.04.031
4. [4]
  Li M X, Zhang L Z, Yang M, et al. Bioorg. Med. Chem. Lett., 2012, 22:2418-2433 doi: 10.1016/j.bmcl.2012.02.024
5. [5]
  Li M X, Zhang L Z, Zhang D, et al. Eur. J. Med. Chem., 2011, 46:4383-4390 doi: 10.1016/j.ejmech.2011.07.009
6. [6]
  Matesanz A I, Leitao I, Souza P. J. Inorg. Biochem., 2013, 125:26-31 doi: 10.1016/j.jinorgbio.2013.04.005
7. [7]
  Matesanz A I, Souza P. Inorg. Chem. Commun., 2013, 27:5-8 doi: 10.1016/j.inoche.2012.10.022
8. [8]
  Qi J, Su L, Gou Y, et al. Eur. J. Med. Chem., 2015, 96:360-368 doi: 10.1016/j.ejmech.2015.04.031
9. [9]
  Jansson P J, Sharpe P C, Bernhardt P V, et al. J. Med. Chem., 2010, 53:5759-5769 doi: 10.1021/jm100561b
10. [10]
  Bacher F, Enyedy E A, Nagy N V, et al. Inorg. Chem., 2013, 52:8895-8908 doi: 10.1021/ic401079w
11. [11]
  Enyedy E A, Primik M F, Kowol C R, et al. Dalton Trans., 2011, 40:5895-5905 doi: 10.1039/c0dt01835j
12. [12]
  Bourosh P N, Revenko M D, Stratulat E F, et al. Russ. J. Inorg.Chem., 2014, 59:545-557 doi: 10.1134/S0036023614060059
13. [13]
  Revenko M D, Bourosh P N, Stratulat E F, et al. Russ. J. Inorg. Chem., 2010, 55:1387-1397 doi: 10.1134/S0036023610090093
14. [14]
  MAO Pan-Dong, YAN Ling-Ling, WANG Wen-Jing, et al. Chinese J. Inorg. Chem., 2016, 32:555-561
15. [15]
  Sheldrick G M. SADABS, University of Göttingen, Germany, 1996.
16. [16]
  Sheldrick G M. SHELX-97, Program for the Solution and the Refinement of Crystal Structures, University of Göttingen, Germany, 1997.
17. [17]
  Yang Z Y, Wang Y, Wang Y. Bioorg. Med. Chem. Lett., 2007, 17:2096-2101 doi: 10.1016/j.bmcl.2006.10.049
18. [18]
  SHEN Wei, HU Wei-Ji, WU Xiao-Yong, et al. Chinese J. Inorg. Chem., 2016, 32:1101-1110
19. [19]
  Nath M, Vats M, Roy P. Eur. J. Med. Chem., 2013, 59:310-321 doi: 10.1016/j.ejmech.2012.11.023
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