Citation: LIU Xiang-Rong, SUN Xiu-Chao, YANG Zai-Wen, ZHAO Shun-Sheng, YANG Shui-Lan, YAN Sen. 2-Furancarbaldehyde-4-hydroxy-benzoylhydrazone and Its Cu (Ⅱ) Complex: Crystal Structures and Binding Ability with CT-DNA[J]. Chinese Journal of Inorganic Chemistry, ;2016, 32(2): 250-258. doi: 10.11862/CJIC.2016.037 shu

2-Furancarbaldehyde-4-hydroxy-benzoylhydrazone and Its Cu (Ⅱ) Complex: Crystal Structures and Binding Ability with CT-DNA

College of Chemistry and Chemical Engineering, Xi′an University of Science and Technology, Xi′an 710054, China

Corresponding author: LIU Xiang-Rong, liuxiangrongxk@163.com
Received Date: 19 August 2015
Revised Date: 22 November 2015

Figures(17)

2-furancarbaldehyde-4-hydroxy-benzoylhydrazone (H₂L) was synthesized from 4-hydroxybenzoylhydrazine and 2-furancarbaldehyde, and its Cu (Ⅱ) coordination polymer [Cu (HL)₂]·2H₂O (1) also was prepared. H₂L and 1 were characterized by elemental analysis and single crystal X-ray diffraction analysis. The crystal structural analyses show that the crystal of H₂L belongs to orthorhombic system space group Pna2₁, and the crystal of 1 crystallizes in monoclinic system space group P2₁/c. Thermal gravity analyses were used to investigate the thermal stabilities of H₂L and 1, and their apparent activation energy of the decompositions were also calculated. It was found that both of the complex and the ligand possessed higher thermal stability. The binding modes of H₂L and 1 with CT-DNA were studied by UV-Vis absorption, and their interaction enthalpies were measured by microcalorimetry. The results showed that the interaction of H₂L and 1 with CT-DNA belonged to partial intercalation mode and 1 presented stronger interaction with CT-DNA than H₂L. CCDC: 1030242, H₂L; 1401955, 1.
- hydrazone compounds,
- Cu (Ⅱ) complex,
- crystal structure,
- CT-DNA,
- microcalorimetry
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