Citation: XU Zhou-Qing, MAO Xian-Jie, ZHANG Xin, CAI Hong-Xin, BIE Hong-Yan, XU Jun, JIA Lei. Syntheses, Crystal Structures and Antitumor Activities of Three Ln(Ⅲ) Complexes with 2-Acetylpyridine Picolinohydrazone[J]. Chinese Journal of Inorganic Chemistry, ;2015, (11): 2249-2256. doi: 10.11862/CJIC.2015.281 shu

Syntheses, Crystal Structures and Antitumor Activities of Three Ln(Ⅲ) Complexes with 2-Acetylpyridine Picolinohydrazone

XU Zhou-Qing ¹ ,
MAO Xian-Jie ¹ ,
ZHANG Xin ² ,
CAI Hong-Xin ^1,, ,
BIE Hong-Yan ^1,, ,
XU Jun ¹ ,
JIA Lei ¹

1.
1 Department of Physics and Chemistry, Henan Polytechnic University, Jiaozuo, Henan 454000, China;
2.
2 College of Agricultural and Biotechnology, China Agriculture University, Beijing 100083, China

Corresponding author: CAI Hong-Xin, BIE Hong-Yan,
Received Date: 1 June 2015
Available Online: 15 July 2015
Fund Project: 国家自然科学基金(No.21404033,21401046,51202060) (No.21404033,21401046,51202060)河南理工大学博士基金(No.72103/001/103)资助项目。 (No.72103/001/103)

Three lathanide(Ⅲ) complexes, namely [Ln(HL)(NO₃)₃(CH₃OH)₂] (Ln=La, 1; Ce, 2) and [Nd(HL)(NO₃)₃(H₂O)]CH₃OH(3) (HL=2-acetylpyridine picolinohydrazone), have been isolated and characterized by elemental analyses, infrared spectra and single-crystal X-ray diffraction analyses. The results reveal that in the isostructure complexes 1 and 2, the eleven coordinated Ln(Ⅲ) ion with mono-capped pentagonal antiprism coordination geometry is surrounded by one HL ligand with N₂O donor sets, three bidentate nitrate anion and two methanol molecules. In the complex 3, the Nd(Ⅲ) ion is coordinated by one HL ligand with N₂O donor sets, three bidentate nitrate anions and one water molecule, thus exhibiting bicapped square antiprism coordination geometry. Furthermore, all the complexes have excellent antitumor activity towards Lovo human colorectal cancer, BGC823 and SGC7901 human gastric cancer cell lines.
- lathanide(Ⅲ) complex;picolinohydrazone;isonicotinohydrazide;antitumor activity
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