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Citation: GAO Chuan-Zhu, CHEN Ji, WANG Tian-Shuai, ZHANG Yan, QIAN Yun-Xu, YANG Bo, GOU Shao-Hua, DONG Peng, ZHANG Ying-Jie. Synthesis and Antitumor Activity of Dinuclear Platinum Complexes with (1iR, 1iiR, 2iR, 2iiR)-Ni, Nii-(1, 3-Phenylenebis(methylene))dicyclohexane-1, 2-diamie as the Ligan[J]. Chinese Journal of Inorganic Chemistry, ;2015, (11): 2188-2196. doi: 10.11862/CJIC.2015.277 shu

Synthesis and Antitumor Activity of Dinuclear Platinum Complexes with (1iR, 1iiR, 2iR, 2iiR)-Ni, Nii-(1, 3-Phenylenebis(methylene))dicyclohexane-1, 2-diamie as the Ligan

  • 1.

    1 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;

  • 2.

    2 Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;

  • 3.

    3 Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650504, China

  • Corresponding author: GAO Chuan-Zhu,  ZHANG Ying-Jie, 
  • Received Date: 10 June 2015
    Available Online: 23 August 2015

    Fund Project: 国家自然科学基金(No.21361014,21302074) (No.21361014,21302074)国家自然科学基金(No.21362016) (No.21362016)教育部博士点基金(No.20125314120007)资助项目。 (No.20125314120007)

  • Seven diculear platinum complexes with the new chiral ligand, (1iR,1iiR,2iR,2iiR)-Ni, Nii-(1,3-phenylenebis(methylene))dicyclohexane-1,2-diamine (HL), were designed, synthesized and spectrally characterized by IR, 1H NMR, 13C NMR, ESI-MS and microanalyses. The cytotoxicities of targeted dinuclear platinum compounds against human HepG-2, A549, HCT-116 and MCF-7 cell lines were evaluated by MTT assay. Results indicated that all compounds exhibited positive activity to HepG-2, A549 and HCT-116 cell lines, but none of them showed activity to MCF-7 cell line. Among them, compound P7, owing to 3-hydroxycyclobutane-1,1-dicarboxylate as the leaving group, gave better antitumor activity than carboplatin against HepG-2 and A549 cell lines, and close cytotoxicity to oxaliplatin against HCT-116 cell line.
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    1. [1]

      [1] Zhang J C, Wang L W, Xing Z Y, et al. Anti-Cancer Agents Med. Chem., 2010,10(4),272-282

    2. [2]

      [2] Connors T A, Cleare M J, Harrap K R. Cancer Treat. Rev., 1979,63(9/10):1499-1502

    3. [3]

      [3] Ho Y P, Au-Yeung S C F, To K K W. Med. Res. Rev., 2003,23(5):633-655

    4. [4]

      [4] Ruhayel R A, Langner J S, Oke M J, et al. J. Am. Chem. Soc., 2012,134(16):7135-7146

    5. [5]

      [5] Wang A H, Nathans J, Marel G, et al. Nature, 1978,276 (5687): 471-474

    6. [6]

      [6] Liu H K, Sadler P J. Acc. Chem. Res., 2011,44(5):349-359

    7. [7]

      [7] de Gramont A, Figer A, Seymour M, et al. J. Clin. Oncol., 2000,18(16):2938-2947

    8. [8]

      [8] Gao C Z, Fei F, Wang T S, et al. J. Coord. Chem., 2013,66 (6):1068-1076

    9. [9]

      [9] Liu F F, Zhou Z P, Gou S H, et al. J. Coord. Chem., 2014, 67(17):2858-2866

    10. [10]

      [10] Gao C Z, Wang T S, Chen J, et al. J. Coord. Chem., 2014, 67(13):2195-2203

    11. [11]

      [11] Lee D W, Ha H J, Lee W K. Synth. Commun., 2007,37(5): 737-742

    12. [12]

      [12] Alley M C, Scudiero D A, Monks A, et al. Cancer Res., 1988,48(3):589-601

    13. [13]

      [13] Zhang J C, Zhang F F, Wang L W, et al. J. Coord. Chem., 2012,65(12):2159-2169

    14. [14]

      [14] ZHANG Jin-Chao(张金超), LI Lu-Wei(李路伟), WANG Li- Wei(王立伟), et al. Chinese J. Inorg. Chem. (无机化学学 报), 2010,26(9):1699-1702

    15. [15]

      [15] Li L W, Zhang J C, Ma L L, et al. J. Coord. Chem., 2013,66 (4):638-649

    16. [16]

      [16] ZHANG Jin-Chao(张金超), WANG Li-Wei(王立伟), LI Lu-Wei(李路伟), et al. Chinese J. Inorg. Chem. (无机化学学 报), 2011,27(3):565-570

    17. [17]

      [17] Enos G, Mambanda A, Jaganyi D. J. Coord. Chem., 2013,66 (24):4280-4291

  • 加载中
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