Citation: CHEN Xiang, CHAO Hui, JI Liang-Nian. New Trends of Ruthenium Complexes as Inhibitors Targeting Topoisomerase and Telomerase[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(9): 1667-1677. doi: 10.11862/CJIC.2015.241 shu

New Trends of Ruthenium Complexes as Inhibitors Targeting Topoisomerase and Telomerase

1.
MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China

Corresponding author: CHAO Hui, JI Liang-Nian,
Received Date: 20 May 2015
Available Online: 15 July 2015
Fund Project: 973项目(No.2015CB85630) (No.2015CB85630)国家自然科学基金(No.21172273,21171177,21471164) (No.21172273,21171177,21471164)教育部高校博士点基金博导类课题(No.20110171110013)资助项目。 (No.20110171110013)

The anti-tumor study of metal complexes, especially the platinum-base drugs, has achieved remarkable success but still facing several problems such as drugs resistance and side effects. Recently, ruthenium complexes attract many scientists' interests with their brand new application of anti-tumor drugs. In the series of non-platinum drugs, ruthenium complexes are regarded as one of the most potential anti-tumor drugs for the reason not merely the metal ruthenium and its complexes exhibit low toxicity but also they can be efficiently absorbed and excreted for human body. Herein, the study of the follow-up inhibition towards nucleus enzymes induced by the binding between ruthenium complexes and DNA was expatiated, introducing the advance anti-tumor applications of ruthenium complexes in new perspectives.
- ruthenium complexes;topoisomerase;G-quadruplex;telomerase
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沈阳化工大学材料科学与工程学院沈阳 110142