Citation: CHEN Xiang, CHAO Hui, JI Liang-Nian. New Trends of Ruthenium Complexes as Inhibitors Targeting Topoisomerase and Telomerase[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(9): 1667-1677. doi: 10.11862/CJIC.2015.241 shu

New Trends of Ruthenium Complexes as Inhibitors Targeting Topoisomerase and Telomerase

1.
MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China

Corresponding author: CHAO Hui, JI Liang-Nian,
Received Date: 20 May 2015
Available Online: 15 July 2015
Fund Project: 973项目(No.2015CB85630) (No.2015CB85630)国家自然科学基金(No.21172273,21171177,21471164) (No.21172273,21171177,21471164)教育部高校博士点基金博导类课题(No.20110171110013)资助项目。 (No.20110171110013)

The anti-tumor study of metal complexes, especially the platinum-base drugs, has achieved remarkable success but still facing several problems such as drugs resistance and side effects. Recently, ruthenium complexes attract many scientists' interests with their brand new application of anti-tumor drugs. In the series of non-platinum drugs, ruthenium complexes are regarded as one of the most potential anti-tumor drugs for the reason not merely the metal ruthenium and its complexes exhibit low toxicity but also they can be efficiently absorbed and excreted for human body. Herein, the study of the follow-up inhibition towards nucleus enzymes induced by the binding between ruthenium complexes and DNA was expatiated, introducing the advance anti-tumor applications of ruthenium complexes in new perspectives.
- ruthenium complexes;topoisomerase;G-quadruplex;telomerase
1. [1]
  [1] Jamieson E J, Lippard S J. Chem. Rev., 1999,99:2467-2498
2. [2]
  [2] Van Zutphen S, Reedijk J. Coord. Chem. Rev., 2005,249:2845-2853
3. [3]
  [3] Fuertes M A, A lonso C, Pérez J M. Chem. Rev., 2003,103:645-662
4. [4]
  [4] Kelland L. Nat. Rev. Cancer, 2007,7:573-584
5. [5]
  [5] Kostova I. Curr. Med. Chem., 2006,13:1085-1107
6. [6]
  [6] Clark M J. Coord. Chem. Rev., 2002,232:69-93
7. [7]
  [7] Bergamo A, Sava G. Dalton Trans., 2007:1267-1272
8. [8]
  [8] CHEN Yu(陈禹), DU Ke-Jie(杜可杰), CHAO Hui(巢晖), et al. Prog. Chem.(化学进展), 2009,5:836-844
9. [9]
  [9] Wang J C. Annu. Rev. Biochem., 1996,65:635-692
10. [10]
  [10] QIAN Chen(钱晨), PENG Zai-Li(彭再利), CHAO Hui (巢晖). Univ. Chem.(大学化学), 2014,29:1-10
11. [11]
  [11] Li T K, Liu L F. Annu. Rev. Pharmacol. Toxicol., 2001,41:53-77
12. [12]
  [12] Malonne H, Atassi G. Anti. Cancer Drugs, 1997,8:811-822
13. [13]
  [13] John L N. Nat. Rev. Cancer, 2009,9:338-350
14. [14]
  [14] MO Xiao-Mei(莫晓媚), LI Jing(李静), GENG Mei-Yu (耿美玉). Chinese Pharmaco. Bull. (中国药理学通报), 2007,1:20-23
15. [15]
  [15] Gopal Y N V, Jayaraju D, Kondapi A K. Biochemistry, 1999, 38:4382-4388
16. [16]
  [16] Gao F, Chao H, Wang J Q, et al. J. Biol. Inorg. Chem., 2007, 12:1015-1027
17. [17]
  [17] Gao F, Chao H, Zhou F, et al. J. Inorg. Biochem., 2008,102:1050-1059
18. [18]
  [18] Eder J P, Chan V, Wong J, et al. Cancer Chemother. Pharmacol., 1998,42:327-335
19. [19]
  [19] Crump M, Lipton J, Hedley D, et al. Leukemia, 1999,13:343-347
20. [20]
  [20] Vey N, Kantarjian H, Beran M, et al. Invest. New Drugs, 1999,17:89-95
21. [21]
  [21] Azarova A M, Lyu Y L, Lin C P, et al. Proc. Natl. Acad. Sci. USA, 2007,107:11014-11019
22. [22]
  [22] Du K J, Wang J Q, Kou J F, et al. Eur. J. Med. Chem., 2011,46:1056-1065
23. [23]
  [23] Kou J F, Qian C, Wang J Q, et al. J. Biol. Inorg. Chem., 2012,17:81-96
24. [24]
  [24] Wang Y C, Qian C, Peng Z L, et al. J. Inorg. Chem., 2014, 130:15-27
25. [25]
  [25] Du K J, Liang J W, Wang Y, et al. Dalton Trans., 2014,43:17303-17316
26. [26]
  [26] Zhang P Y, Wang J Q, Huang H Y, et al. Dalton Trans., 2013,42:8907-8917
27. [27]
  [27] He X J, Jin L H, Tan L F. Spectrochim. Acta A, 2015,135:101-109
28. [28]
  [28] He X J, Zeng L L, Yang G, et al. Inorg. Chim. Acta, 2013, 408:9-17
29. [29]
  [29] Liu X W, Zhang S B, Li L, et al. Organomet. Chem., 2013, 729:1-8
30. [30]
  [30] Liu Y J, Zeng C H, Yao J H, et al. Chem. Biodivers., 2010, 7:1770-1783
31. [31]
  [31] Liu Y J, Zeng C H, Huang H L, et al. Eur. J. Med. Chem., 2011,45:564-571
32. [32]
  [32] Blackburn E H. J. Biol. Chem., 1990,265:5919-5921
33. [33]
  [33] Blackburn E H. Annu. Rev. Biochem., 1984,53:163-194
34. [34]
  [34] Blackburn E H. Nature, 2000,408,53-56
35. [35]
  [35] Liu D, OConnor M S, Qin J, et al. J. Biol. Chem., 2004, 279,51338-51342
36. [36]
  [36] Hiyama K, Hiyama E, Ishioka S, et al. J. Natl. Cancer Inst., 1995,87:895-902
37. [37]
  [37] Counter C M, Hirte H W, Bacchetti S, et al. Proc. Natl. Acad. Sci. USA, 1994,91:2900-2904
38. [38]
  [38] Hiyama E, Yokoyama T, Tatsumoto N, et al. Cancer Res., 1995,55:3258-3262
39. [39]
  [39] Hiyama E, Gollahon L, Kataoka T, et al. J. Natl. Cancer Inst., 1996,88:116-122
40. [40]
  [40] Burge S, Parkinson G N, Hazel P, et al. Nucleic Acids Res., 2006,34:5402-5415
41. [41]
  [41] Monchaud D, Teulade-Fichou M P. Org. Biomol. Chem., 2008, 6:627-636
42. [42]
  [42] Shay J W, Wright W E. Nat. Rev. Drug Discov., 2006,5:577-584
43. [43]
  [43] Shi S, Liu J, Yao T M, et al. Inorg. Chem., 2008,47:2910-2912
44. [44]
  [44] Xu L, Liao G L, Chen X, et al. Inorg. Chem. Commun., 2010,13:1050-10053
45. [45]
  [45] Chen X, Wu J H, Lai Y W, et al. Dalton Trans., 2013,42:4386-4397
46. [46]
  [46] Liao G L, Chen X, Wu J H, et al. Dalton Trans., 2014,43:7811-7819
47. [47]
  [47] Xu L, Chen X, Wu J H, et al. Chem. Eur. J., 2015,21:4008-4020
48. [48]
  [48] Yu Q Q, Liu Y N, Xu L, et al. Eur. J. Med. Chem., 2014, 82:82-95
49. [49]
  [49] Zhang J N, Yu Q Q, Li Q, et al. J. Inorg. Biochem., 2014,134:1-11
50. [50]
  [50] Li Q, Zhang J N, Yang L C, et al. J. Inorg. Biochem., 2014, 130:122-129
51. [51]
  [51] Xia Y, Chen Q C, Qin X Y, et al. New J. Chem., 2013,37:3706-3715
52. [52]
  [52] Li Q, Sun D D, Zhou Y H, et al. Inorg. Chem. Commun., 2012,20:142-146
53. [53]
  [53] Yu Q Q, Liu Y Y, Zhang J N, et al. Metallomics, 2013,5:222-231
54. [54]
  [54] Sun D D, Zhang R, Yuan F, et al. Dalton Trans., 2012,41:1734-1741
55. [55]
  [55] Yu Q Q, Liu Y N, Wang C, et al. PloS one, 2012,7:e50902
56. [56]
  [56] Sun D D, Liu Y N, Liu D, et al. Chem. Eur. J., 2012,18:4285-4295
57. [57]
  [57] Shi S, Gao S N, Cao T C, et al. PloS one, 2013,8:e84419
58. [58]
  [58] Kim M Y, Duan W, Guzman M G, et al. J. Med. Chem., 2003, 46:571-583
59. [59]
  [59] Von S T, Seng H L, Lee H B, et al. J. Biol. Inorg. Chem., 2012,17:57-69
60. [60]
  [60] Liao G L, Chen X, Wu J H, et al. Dalton Trans., 2015,DOI:10.1039/c4dt03585b
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沈阳化工大学材料科学与工程学院沈阳 110142