Citation: SUN Jing-Hua, ZHANG Wei, TAN Cai-Ping, JI Liang-Nian, MAO Zong-Wan. Synthesis of β-Cyclodextrin Functionalized Fluorescent Gold Nanoclusters for Cellular Imaging[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(9): 1913-1918. doi: 10.11862/CJIC.2015.239 shu

Synthesis of β-Cyclodextrin Functionalized Fluorescent Gold Nanoclusters for Cellular Imaging

1.
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry;Sun Yat-sen University, School of Chemistry and Chemical Engineering, Guangzhou 510275, China

Corresponding author: MAO Zong-Wan,
Received Date: 9 July 2015
Available Online: 27 July 2015
Fund Project: 国家自然科学基金(No.21231007) (No.21231007)国家重点基础研究发展计划(973计划)(No.2014CB845604)资助项目。 (973计划)(No.2014CB845604)

A new kind of highly fluorescent AuNCs functionalized with β-cyclodextrin (CD) was prepared by using one-pot aqueous reduction of gold precursor. Aqueous dispersion of these red AuNCs exhibits good long-term colloidal stability as well as fluorescent stability. The average diameter of AuNCs-CD is (1.40±0.32) nm as determined by transmission electron microscopy (TEM). Confocal microscopic observation shows that AuNCs-CD can penetrate into cells and mainly localize within the cytoplasm. In vitro cytotoxicity assay indicates that the AuNCs-CD displays very low cytotoxicity against human lung adenocarcinoma A549 cells. Cyclodextrin modification is expected to make AuNCs more versatile for encapsulation of hydrophobic drugs and functionalization with targeting moieties, which will broaden the potential of AuNCs-CD for biomedical applications.
- β-cyclodextrin;gold nanoclusters;cellular imaging
1. [1]
  [1] Choi S, Dickson R M, Yu J. Chem. Soc. Rev., 2012,41(5):1867-1891
2. [2]
  [2] Tanaka S I, Miyazaki J, Tiwari D K, et al. Angew. Chem. Int. Ed., 2011,123(2):451-455
3. [3]
  [3] Yuan X, Luo Z, Zhang Q, et al. ACS Nano, 2011,5(11):8800-8808
4. [4]
  [4] Zhang H, Huang X, Li L, et al. Chem. Commun., 2011,48(4):567-569
5. [5]
  [5] Shang L, Dong S, Nienhaus G U. Nano Today, 2011,6(4):401-418
6. [6]
  [6] Shang L, Azadfar N, Stockmar F, et al. Small, 2011,7(18):2614-2620
7. [7]
  [7] Wu Z, Suhan J, Jin R. J. Mater. Chem., 2009,19(5):622-626
8. [8]
  [8] Xie J, Zheng Y, Ying J Y. J. Am. Chem. Soc., 2009,131(3):888-889
9. [9]
  [9] Biju V. Chem. Soc. Rev., 2014,43(3):744-764
10. [10]
  [10] Huang C C, Liao H Y, Shiang Y C, et al. J. Mater. Chem., 2009,19(6):755-759
11. [11]
  [11] Shang L, Stockmar F, Azadfar N, et al. Angew. Chem. Int. Ed., 2013,52(42):11154-11157
12. [12]
  [12] Chen T, Hu Y, Cen Y, et al. J. Am. Chem. Soc., 2013,135(31):11595-11602
13. [13]
  [13] Palmal S, Basiruddin S, Maity A R, et al. Chem. Eur. J., 2013,19(3):943-949
14. [14]
  [14] Sun J, Jin Y. J. Mater. Chem. C, 2014,2(38):8000-8011
15. [15]
  [15] Schmid G, Fenske D. Phil. Trans. R. Soc. A, 2010,368(1915):1207-1210
16. [16]
  [16] Li J J, Wang Y A, Guo W, et al. J. Am. Chem. Soc., 2003, 125(41):12567-12575
17. [17]
  [17] Stewart M H, Susumu K, Mei B C, et al. J. Am. Chem. Soc., 2010,132(28):9804-9813
18. [18]
  [18] Liu C L, Wu H T, Hsiao Y H, et al. Angew. Chem. Int. Ed., 2011,50(31):7056-7560
19. [19]
  [19] Polavarapu L, Manna M, Xu Q H. Nanoscale, 2011,3(2):429-434
20. [20]
  [20] Chen G, Jiang M. Chem. Soc. Rev., 2011,40(5):2254-2266
21. [21]
  [21] Hu Q D, Tang G P, Chu P K. Acc. Chem. Res., 2014,47(7):2017-2025
22. [22]
  [22] Lai W F. Biomaterials, 2014,35(1):401-411
23. [23]
  [23] Li J M, Wang Y Y, Zhao M X, et al. Biomaterials, 2012,33(9):2780-2790
24. [24]
  [24] Zhao M X, Li J M, Du L, et al. Chem. Eur. J., 2011,17(18):5171-5179
25. [25]
  [25] Shen J, Kim H C, Su H, et al. Theranostics, 2014,4(5):487-489
26. [26]
  [26] Park C, Youn H, Kim H, et al. J. Mater. Chem., 2009,19(16):2310-2315
27. [27]
  [27] He H, Chen S, Zhou J, et al. Biomaterials, 2013,34(21):5344-5358
28. [28]
  [28] Petter R C, Salek J S, Sikorski C T, et al. J. Am. Chem. Soc., 1990,112(10):3860-3868
29. [29]
  [29] May B, Kean S, Easton C, et al. J. Chem. Soc., Perkin Trans. 1, 1997(21):3157-3160
30. [30]
  [30] Liu Y, You C C, Wada T, et al. Tetrahedron Lett., 2000,41(35):6869-6873
31. [31]
  [31] Aldeek F, Muhammed M A H, Palui G, et al. ACS Nano, 2013,7(3):2509-2521
32. [32]
  [32] Negishi Y, Nobusada K, Tsukuda T. J. Am. Chem. Soc., 2005,127(14):5261-5270
33. [33]
  [33] Muhammed M A H, Verma P K, Pal S K, et al. Chem. Eur. J., 2009,15(39):10110-10120
34. [34]
  [34] Yau S H, Varnavski O, Goodson T. Acc. Chem. Res., 2013, 46(7):1506-1516
1. [1]
  Jiakun BAI , Ting XU , Lu ZHANG , Jiang PENG , Yuqiang LI , Junhui JIA . A red-emitting fluorescent probe with a large Stokes shift for selective detection of hypochlorous acid. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1095-1104. doi: 10.11862/CJIC.20240002
2. [2]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
3. [3]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
4. [4]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
5. [5]
  Peng ZHOU , Xiao CAI , Qingxiang MA , Xu LIU . Effects of Cu doping on the structure and optical properties of Au₁₁(dppf)₄Cl₂ nanocluster. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1254-1260. doi: 10.11862/CJIC.20240047
6. [6]
  Zongfei YANG , Xiaosen ZHAO , Jing LI , Wenchang ZHUANG . Research advances in heteropolyoxoniobates. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 465-480. doi: 10.11862/CJIC.20230306
7. [7]
  Donghui PAN , Yuping XU , Xinyu WANG , Lizhen WANG , Junjie YAN , Dongjian SHI , Min YANG , Mingqing CHEN . Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 669-676. doi: 10.11862/CJIC.20230468
8. [8]
  Xinyu ZENG , Guhua TANG , Jianming OUYANG . Inhibitory effect of Desmodium styracifolium polysaccharides with different content of carboxyl groups on the growth, aggregation and cell adhesion of calcium oxalate crystals. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1563-1576. doi: 10.11862/CJIC.20230374
9. [9]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
10. [10]
  Huan LI , Shengyan WANG , Long Zhang , Yue CAO , Xiaohan YANG , Ziliang WANG , Wenjuan ZHU , Wenlei ZHU , Yang ZHOU . Growth mechanisms and application potentials of magic-size clusters of groups Ⅱ-Ⅵ semiconductors. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1425-1441. doi: 10.11862/CJIC.20240088
11. [11]
  Jiao CHEN , Yi LI , Yi XIE , Dandan DIAO , Qiang XIAO . Vapor-phase transport of MFI nanosheets for the fabrication of ultrathin b-axis oriented zeolite membranes. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 507-514. doi: 10.11862/CJIC.20230403
12. [12]
  Guimin ZHANG , Wenjuan MA , Wenqiang DING , Zhengyi FU . Synthesis and catalytic properties of hollow AgPd bimetallic nanospheres. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 963-971. doi: 10.11862/CJIC.20230293
13. [13]
  Yuhao SUN , Qingzhe DONG , Lei ZHAO , Xiaodan JIANG , Hailing GUO , Xianglong MENG , Yongmei GUO . Synthesis and antibacterial properties of silver-loaded sod-based zeolite. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 761-770. doi: 10.11862/CJIC.20230169
14. [14]
  Jingke LIU , Jia CHEN , Yingchao HAN . Nano hydroxyapatite stable suspension system: Preparation and cobalt adsorption performance. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1763-1774. doi: 10.11862/CJIC.20240060
15. [15]
  Wenjiang LI , Pingli GUAN , Rui YU , Yuansheng CHENG , Xianwen WEI . C₆₀-MoP-C nanoflowers van der Waals heterojunctions and its electrocatalytic hydrogen evolution performance. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 771-781. doi: 10.11862/CJIC.20230289
16. [16]
  Siyu HOU , Weiyao LI , Jiadong LIU , Fei WANG , Wensi LIU , Jing YANG , Ying ZHANG . Preparation and catalytic performance of magnetic nano iron oxide by oxidation co-precipitation method. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1577-1582. doi: 10.11862/CJIC.20230469
17. [17]
  Guangming YIN , Huaiyao WANG , Jianhua ZHENG , Xinyue DONG , Jian LI , Yi'nan SUN , Yiming GAO , Bingbing WANG . Preparation and photocatalytic degradation performance of Ag/protonated g-C₃N₄ nanorod materials. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1491-1500. doi: 10.11862/CJIC.20240086
18. [18]
  Qi Li , Pingan Li , Zetong Liu , Jiahui Zhang , Hao Zhang , Weilai Yu , Xianluo Hu . Fabricating Micro/Nanostructured Separators and Electrode Materials by Coaxial Electrospinning for Lithium-Ion Batteries: From Fundamentals to Applications. Acta Physico-Chimica Sinica, 2024, 40(10): 2311030-. doi: 10.3866/PKU.WHXB202311030
19. [19]
  Chunmei GUO , Weihan YIN , Jingyi SHI , Jianhang ZHAO , Ying CHEN , Quli FAN . Facile construction and peroxidase-like activity of single-atom platinum nanozyme. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1633-1639. doi: 10.11862/CJIC.20240162
20. [20]
  Qingtang ZHANG , Xiaoyu WU , Zheng WANG , Xiaomei WANG . Performance of nano Li₂FeSiO₄/C cathode material co-doped by potassium and chlorine ions. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1689-1696. doi: 10.11862/CJIC.20240115

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(304)
HTML views(58)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142