Citation: SUN Jing-Hua, ZHANG Wei, TAN Cai-Ping, JI Liang-Nian, MAO Zong-Wan. Synthesis of β-Cyclodextrin Functionalized Fluorescent Gold Nanoclusters for Cellular Imaging[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(9): 1913-1918. doi: 10.11862/CJIC.2015.239 shu

Synthesis of β-Cyclodextrin Functionalized Fluorescent Gold Nanoclusters for Cellular Imaging

1.
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry;Sun Yat-sen University, School of Chemistry and Chemical Engineering, Guangzhou 510275, China

Corresponding author: MAO Zong-Wan,
Received Date: 9 July 2015
Available Online: 27 July 2015
Fund Project: 国家自然科学基金(No.21231007) (No.21231007)国家重点基础研究发展计划(973计划)(No.2014CB845604)资助项目。 (973计划)(No.2014CB845604)

A new kind of highly fluorescent AuNCs functionalized with β-cyclodextrin (CD) was prepared by using one-pot aqueous reduction of gold precursor. Aqueous dispersion of these red AuNCs exhibits good long-term colloidal stability as well as fluorescent stability. The average diameter of AuNCs-CD is (1.40±0.32) nm as determined by transmission electron microscopy (TEM). Confocal microscopic observation shows that AuNCs-CD can penetrate into cells and mainly localize within the cytoplasm. In vitro cytotoxicity assay indicates that the AuNCs-CD displays very low cytotoxicity against human lung adenocarcinoma A549 cells. Cyclodextrin modification is expected to make AuNCs more versatile for encapsulation of hydrophobic drugs and functionalization with targeting moieties, which will broaden the potential of AuNCs-CD for biomedical applications.
- β-cyclodextrin;gold nanoclusters;cellular imaging
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