Citation: SONG Xiao-Li, LUO Xia-Dan, LI Ling, ZHU Ai-Ping. Preparation and Liver MRI of Fe₃O₄/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(10): 1987-1992. doi: 10.11862/CJIC.2015.230 shu

Preparation and Liver MRI of Fe₃O₄/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent

SONG Xiao-Li ^1,, ,
LUO Xia-Dan ² ,
LI Ling ¹ ,
ZHU Ai-Ping ^1,,

1.
1 College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China;
2.
2 Jinhua Research Academy of Environmental Sciences, Jinhua, Zhejiang 321000, China

Corresponding author: SONG Xiao-Li, ZHU Ai-Ping,
Received Date: 11 March 2015
Available Online: 26 June 2015
Fund Project: 国家自然科学基金(No.21201149) (No.21201149)江苏省自然科学基金(BK2012259)资助项目。 (BK2012259)

Supermagnetic Fe₃O₄/N-(2-hydroxyl)propyl-3-trimethyl ammonium chitosan nanoparticles were synthesized by combining Fe₃O₄ and CS chemically modified with glycidyl trimethyl ammonium chloride. Properties of the obtained nanoparticles were investigated by transmission electron microscopy, dynamic light scattering, magnetic resonance imaging and vibration sample magnetometer. The cytocompatibility of the nanoparticles were assessed. Then the in vivo MRI of the nanoparticles were confirmed. The results demonstrate that the nanoparticles are uniform and stable in simulated physiological environment. Also the nanoparticles show good cyto-compatibility. The in vivo results show that the parenchyma signal intensity of rats liver is significantly decreased after injection of the nanoparticles. Thus it indicates that the nanoparticles have potential application in liver MRI as a negative contrast.
- N-(2-hydroxyl)propyl-3-trimethyl ammonium chitosan;supermagnetic Fe₃O₄;suspension stablility;magnetic resonance imaging
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Preparation and Liver MRI of Fe₃O₄/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent