Citation: HE Miao, JIAO Qing-Zhu, CHEN Xiang-Fei, LI Jian, CHEN Jie, SHENG Gui-Hua, YOU Zhong-Lu. Syntheses, Characterization, Crystal Structures and Insulin-Like Activity of Vanadium(Ⅴ) Complexes with Aroylhydrazone and Maltol Mixed-Ligands[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(8): 1590-1596. doi: 10.11862/CJIC.2015.174 shu

Syntheses, Characterization, Crystal Structures and Insulin-Like Activity of Vanadium(Ⅴ) Complexes with Aroylhydrazone and Maltol Mixed-Ligands

1.
1. Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China;
2.
2. School of Life Sciences, Shandong University of Technology, Zibo, Shandong 255049, China

Corresponding author: JIAO Qing-Zhu, YOU Zhong-Lu,
Received Date: 16 April 2015
Available Online: 23 April 2015
Fund Project: 辽宁省高校优秀青年人才支持计划(No.LR2014032)资助项目。 (No.LR2014032)

Two vanadium(Ⅴ) complexes, [VOLL¹] (1) and [VOLL²] (1) (L=N'-(3,5-dibromo-2-hydroxybenzylidene)-3-methylbenzohydrazide, L¹=methylmaltol, L²=ethylmaltol), have been prepared. The complexes have been characte-rized by physico-chemical methods and single crystal X-ray determination. The V atom in each complex is coordinated by three donor atoms of L, two donor atoms of L¹ or L², and one oxo group, forming octahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mices for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mgV·kg^-1, can significantly decrease the blood glucose level in alloxan-diabetic mices, but the blood glucose level in the treated normal mices was not altered. CCDC: 1059791, 1; 1059793, 2.
- vanadium complex;aroylhydrazone;crystal structure;insulin-like activity
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